Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2019
Predictors of transfusion outcomes in pediatric complex cranial vault reconstruction: a multicentre observational study from the Pediatric Craniofacial Collaborative Group.
Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 35 citations in OpenAlex.
- Preoperative Prediction of Intraoperative Transfusion in Pediatric Craniosynostosis Surgery: An Exploratory Prediction Model Study.Medicina (Kaunas, Lithuania) · 2026Article
- Multidisciplinary Collaborative Efforts in Craniosynostosis Surgery-A Rural Appalachian Institutional Experience in Patient Care and Outcomes.International journal of pediatrics · 2025Article
- Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis.Critical care explorations · 2021Article
- Intraoperative transfusion practice in burned children in a university hospital over four years: a retrospective analysis.BMC anesthesiology · 2021Article
- A Quality Improvement Project to Limit Perioperative Transfusion During Craniofacial Surgery in Infants and Children.Pediatric quality & safetyArticle
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePediatric patients undergoing complex cranial vault reconstruction (CCVR) are at risk of significant perioperative blood loss requiring blood product transfusion. Minimizing allogeneic blood product transfusion is an important goal because of the associated risks and cost. The impact of patient and surgical variables on transfusion is unknown in this population. Our primary aim was to examine relationships between demographic and perioperative variables and blood product transfusion outcomes in CCVR.
methodsThe multicentre Pediatric Surgery Perioperative Registry was checked for children undergoing CCVR between June 2012 and September 2016. Univariable and multivariable analyses were performed examining patient, procedure, and blood conservation variables and their relationship to three outcomes: intraoperative red blood cell-containing product (RBC-CP) transfusion, total perioperative blood donor exposures, and transfusion-free hospitalization.
resultsThe registry search returned data from 1,814 cases. Age and surgical duration were the only variables significantly associated with all three outcomes studied. Predictors of reduced RBC-CP transfusion included lower American Society of Anesthesiologists (ASA) physical status and antifibrinolytic administration. Total cranial vault reconstruction, intraoperative vasoactive infusion, and presence of a tracheostomy predicted increased donor exposures. Increased body weight, higher preoperative hematocrit, and utilization of intraoperative cell saver and transfusion protocols were associated with transfusion-free hospitalization.
conclusionClinical factors associated with increased allogeneic blood product transfusion in pediatric CCVR include: age ≤ 24 months, ASA status ≥ III, preoperative anemia, prolonged surgical duration, lack of intraoperative antifibrinolytic use, lack of intraoperative cell saver use, and the lack of transfusion protocols.
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