Evidence map›Paper›PMID 30767174›Full record

ArticleJournal of neurovirology2019

Progressive brain atrophy in chronically infected and treated HIV+ individuals.

Talia M Nir, Neda Jahanshad, Christopher R K Ching, Ronald A Cohen, Jaroslaw Harezlak, Giovanni Schifitto, Hei Y Lam, Xue Hua, Jianhui Zhong, Tong Zhu and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

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  9. Dialysis adequacy and hemoglobin levels predict cerebral atrophy in maintenance-hemodialysis patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Talia M NirImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way Suite 200, Marina del Rey, Los Angeles, CA, 90292, USA.ORCID 0000-0002-7106-7443
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way Suite 200, Marina del Rey, Los Angeles, CA, 90292, USA.
Christopher R K ChingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way Suite 200, Marina del Rey, Los Angeles, CA, 90292, USA.
Ronald A CohenDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Jaroslaw HarezlakIndiana University School of Public Health, Bloomington, IN, USA.
Giovanni SchifittoDepartment of Neurology, University of Rochester, Rochester, NY, USA.
Hei Y LamImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way Suite 200, Marina del Rey, Los Angeles, CA, 90292, USA.
Xue HuaImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way Suite 200, Marina del Rey, Los Angeles, CA, 90292, USA.
Jianhui ZhongDepartment of Imaging Sciences, University of Rochester, Rochester, NY, USA.
Tong ZhuDepartment Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA.
Michael J TaylorDepartment of Psychiatry, University of California, San Diego, CA, USA.
Thomas B CampbellMedicine/Infectious Diseases, University of Colorado Denver, Aurora, CO, USA.
Eric S DaarLos Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, University of California, Los Angeles, CA, USA.
Elyse J SingerDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jeffry R AlgerDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way Suite 200, Marina del Rey, Los Angeles, CA, 90292, USA. pthomp@usc.edu.
Bradford A NaviaDepartment of Public Health, Infection Unit, Tufts University School of Medicine, Boston, MA, USA.
HIV Neuroimaging Consortium
University of Southern California · USUniversity of California, Los Angeles · USUniversity of Rochester · USIndiana University Bloomington · USTufts University · USUniversity of California San Diego · USUniversity of Colorado Denver · USUniversity of Florida · USUniversity of North Carolina at Chapel Hill · US

Funding

California NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9M
NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Predicting Brain Changes in HIV/AIDSR01NS080655 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAVIA, BRADFORD, THOMPSON, PAUL M · 2012 to 2015
$2.3M
NIBIB NIH HHS U54 EB020403NIMH NIH HHS U24 MH100928NIMH NIH HHS U24 MH100929NINDS NIH HHS R01 NS080655
6 · The paper itself

Abstract

Growing evidence points to persistent neurological injury in chronic HIV infection. It remains unclear whether chronically HIV-infected individuals on combined antiretroviral therapy (cART) develop progressive brain injury and impaired neurocognitive function despite successful viral suppression and immunological restoration. In a longitudinal neuroimaging study for the HIV Neuroimaging Consortium (HIVNC), we used tensor-based morphometry to map the annual rate of change of regional brain volumes (mean time interval 1.0 ± 0.5 yrs), in 155 chronically infected and treated HIV+ participants (mean age 48.0 ± 8.9 years; 83.9% male) . We tested for associations between rates of brain tissue loss and clinical measures of infection severity (nadir or baseline CD4+ cell count and baseline HIV plasma RNA concentration), HIV duration, cART CNS penetration-effectiveness scores, age, as well as change in AIDS Dementia Complex stage. We found significant brain tissue loss across HIV+ participants, including those neuro-asymptomatic with undetectable viral loads, largely localized to subcortical regions. Measures of disease severity, age, and neurocognitive decline were associated with greater atrophy. Chronically HIV-infected and treated individuals may undergo progressive brain tissue loss despite stable and effective cART, which may contribute to neurocognitive decline. Understanding neurological complications of chronic infection and identifying factors associated with atrophy may help inform strategies to maintain brain health in people living with HIV.

Indexed as

AdultAnti-Retroviral AgentsAtrophyBrainDiffusion Tensor ImagingFemaleHIV InfectionsHumansMaleMiddle AgedAnti-Retroviral AgentsADCBrain volumecARTHIVMRITBM

Identifiers

PMID30767174
PMCPMC6635004
OpenAlexW2912461714

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.