Evidence map›Paper›PMID 30767132›Full record

ArticleAnnals of biomedical engineering2019

A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium.

Y-C Lu, N P Daphalapurkar, A K Knutsen, J Glaister, D L Pham, J A Butman, J L Prince, P V Bayly, K T Ramesh

Abstract read
In one paragraph

Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026
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  5. Data-driven Uncertainty Quantification in Computational Human Head Models.Computer methods in applied mechanics and engineering · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Y-C LuHopkins Extreme Materials Institute, Johns Hopkins University, Baltimore, MD, USA.
N P DaphalapurkarHopkins Extreme Materials Institute, Johns Hopkins University, Baltimore, MD, USA.
A K KnutsenCenter for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
J GlaisterDepartment of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
D L PhamCenter for Neuroscience and Regenerative Medicine, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
J A ButmanNational Institutes of Health Clinical Center, Bethesda, MD, USA.
J L PrinceDepartment of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
P V BaylyDepartment of Mechanical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
K T RameshHopkins Extreme Materials Institute, Johns Hopkins University, Baltimore, MD, USA. ramesh@jhu.edu.ORCID http://orcid.org/0000-0003-2659-4698

Funding

IN VIVO MEASUREMENT OF BRAIN BIOMECHANICSR01NS055951 · NINDS · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2007 to 2017
$3.9M
In Vivo Measurement of Brain BiomechanicsR56NS055951 · NINDS · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2018 to 2018
$563k
NINDS NIH HHS NS055951NINDS NIH HHS R01 NS055951NINDS NIH HHS R56 NS055951
6 · The paper itself

Abstract

We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. We then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.

Indexed as

Models, BiologicalAnisotropyBiomechanical PhenomenaBrainHeadHumansMaleMiddle AgedRotationBrain modelingIn vivo experimentsTBIValidation

Identifiers

PMID30767132
PMCPMC6693976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.