ArticleCognitive, affective & behavioral neuroscience2019
Hippocampal contributions to value-based learning: Converging evidence from fMRI and amnesia.
Article in Cognitive, affective & behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Temporal Dynamics of Reward Dysfunction in Psychiatric Disorders: Memory-Derived Value, Incentive Salience, Hedonic Impact, and Value Updating.Biological psychiatry global open science · 2026Review
- Striatal and hippocampal contributions to value-based learning in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Hippocampus Functional Connectivity, Impulsivity, and Subsequent Substance Use.Journal of cellular neuroscience · 2025Article
- Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut.Metabolic brain disease · 2024Article
- The role of the human hippocampus in decision-making under uncertainty.Nature human behaviour · 2024Article
- Grid-like entorhinal representation of an abstract value space during prospective decision making.Nature communications · 2024Article
- Option similarity modulates the link between choice and memory.Memory & cognition · 2024Article
- The Hippocampus Contributes to Temporal Discounting When Delays and Rewards Are Experienced in the Moment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- HippocampalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Executive Function Assigns Value to Novel Goal-Congruent Outcomes.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress.PloS one · 2021Article
- Article
- Adolescent substance use and functional connectivity between the ventral striatum and hippocampus.Behavioural brain research · 2020Article
- Reward systems, cognition, and emotion: Introduction to the special issue.Cognitive, affective & behavioral neuroscience · 2019Article
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Authors and funding
4 authors.
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Abstract
Recent evidence suggests that the human hippocampus-known primarily for its involvement in episodic memory-plays a role in a host of motivationally relevant behaviors, including some forms of value-based decision-making. However, less is known about the role of the hippocampus in value-based learning. Such learning is typically associated with a striatal system, yet a small number of studies, both in human and nonhuman species, suggest hippocampal engagement. It is not clear, however, whether this engagement is necessary for such learning. In the present study, we used both functional MRI (fMRI) and lesion-based neuropsychological methods to clarify hippocampal contributions to value-based learning. In Experiment 1, healthy participants were scanned while learning value-based contingencies (whether players in a "game" win money) in the context of a probabilistic learning task. Here, we observed recruitment of the hippocampus, in addition to the expected ventral striatal (nucleus accumbens) activation that typically accompanies such learning. In Experiment 2, we administered this task to amnesic patients with medial temporal lobe damage and to healthy controls. Amnesic patients, including those with damage circumscribed to the hippocampus, failed to acquire value-based contingencies, thus confirming that hippocampal engagement is necessary for task performance. Control experiments established that this impairment was not due to perceptual demands or memory load. Future research is needed to clarify the mechanisms by which the hippocampus contributes to value-based learning, but these findings point to a broader role for the hippocampus in goal-directed behaviors than previously appreciated.
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