Evidence map›Paper›PMID 30767045›Full record

Trial reportInternational journal of colorectal disease2019

Prevalence of alpha-1-antitrypsin deficiency carriers in a population with and without colonic diverticula. A multicentre prospective case-control study: the ALADDIN study.

S J Rottier, J de Jonge, L C Dreuning, J van Pelt, A A W van Geloven, X D Y Beele, P M Huisman, W Y Deurholt, C A Rottier, M A Boermeester and 2 more

Open access · hybridAbstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Alpha-1-antitrypsin deficiency (carrier) as possible risk factor for development of colonic diverticula. A multicentre prospective case-control study: the ALADDIN study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

S J RottierDepartment of Surgery, Northwest Clinics, Wilhelminalaan 12, 1815 JD, Alkmaar/Den Helder, Netherlands. s.j.rottier@amc.nl.ORCID http://orcid.org/0000-0003-4996-8162
J de JongeDepartment of Surgery, Tergooi, Hilversum, Netherlands.
L C DreuningDepartment of Surgery, Tergooi, Hilversum, Netherlands.
J van PeltDepartment of Clinical laboratory, Northwest Clinics, Alkmaar/Den Helder, Netherlands.
A A W van GelovenDepartment of Surgery, Tergooi, Hilversum, Netherlands.
X D Y BeeleDepartment of Radiology, Tergooi, Hilversum, Netherlands.
P M HuismanDepartment of Radiology, Tergooi, Hilversum, Netherlands.
W Y DeurholtDepartment of Radiology, Northwest Clinics, Alkmaar/Den Helder, Netherlands.
C A RottierDepartment of Surgery, Northwest Clinics, Wilhelminalaan 12, 1815 JD, Alkmaar/Den Helder, Netherlands.
M A BoermeesterDepartment of Surgery, Amsterdam UMC, Amsterdam, Netherlands.
W H SchreursDepartment of Surgery, Northwest Clinics, Wilhelminalaan 12, 1815 JD, Alkmaar/Den Helder, Netherlands.
ALADDIN Collaborative Study Group
Northwest Hospital · USTergooi · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe underling pathophysiological mechanisms that cause the formation of colonic diverticula (diverticulosis) remain unclear. Connective tissue changes due to ageing that cause changes in collagen structure of the colonic wall is one theory. Alpha-1-antitrypsin (A1AT) is a protease inhibitor known to protect connective tissue in other organs. Associations between (carriers of) A1AT deficiency and the development of colonic diverticula will be the main focus of this study.

methodsA multicentre prospective case-controlled study. In total, 230 patients ≥ 60 years with acute abdominal pain undergoing an abdominal computed tomography (CT) will be included. The research group consists of patients with diverticulosis and/or diverticulitis; controls are patients without diverticula (0 to ≤ 5 diverticula). Genotype analysis for A1AT deficiency will be performed. RATIONALE: Hypothetically, connective tissue changes, in particular related to (carriers of) A1AT deficiency, can contribute to the development of diverticula and diverticulitis. We expect to find a higher prevalence of A1AT carriers in patients with diverticulosis compared to patients without diverticulosis. Having diverticulosis does not affect the general health of these individuals per se, when asymptomatic. Once an association is found, present findings can be the basis for a second study to assess the risk of developing acute diverticulitis and its disease course in carriers of A1AT deficiency. Because a large cohort is needed in the latter, we shall first perform a pilot study to investigate the likelihood of the primary hypothesis.

trial registrationNetherlands Trial register, NTR6251, NL55016.094.15.

Indexed as

alpha 1-Antitrypsin DeficiencyCase-Control StudiesDiverticulum, ColonHeterozygoteHumansProspective StudiesAlpha-1-antitrypsinConnective tissue diseaseDiverticulaDiverticulitisDiverticulosis

Identifiers

PMID30767045
OpenAlexW2912890384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.