Evidence map›Paper›PMID 30766971›Full record

ArticleImmunoHorizons2018

Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies.

Greta Van Slyke, Siva Krishna Angalakurthi, Ronald T Toth, David J Vance, Yinghui Rong, Dylan Ehrbar, Yuqi Shi, C Russell Middaugh, David B Volkin, David D Weis and 1 more

Open access · goldAbstract read
In one paragraph

Article in ImmunoHorizons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. B Cell Epitope Mapping by High-Density Competition ELISAs.Methods in molecular biology (Clifton, N.J.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Greta Van SlykeDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208.ORCID 0000-0003-2646-3030
Siva Krishna AngalakurthiMacromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66045.
Ronald T TothMacromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66045.
David J VanceDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208.ORCID 0000-0002-9913-7722
Yinghui RongDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208.
Dylan EhrbarDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208.
Yuqi ShiDepartment of Chemistry, University of Kansas, Lawrence, KS 66045.
C Russell MiddaughMacromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66045.
David B VolkinMacromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66045.
David D WeisDepartment of Chemistry, University of Kansas, Lawrence, KS 66045.ORCID 0000-0003-3032-1211
Nicholas J MantisDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208.ORCID 0000-0002-5083-8640
University of Kansas · USNew York State Department of Health · US

Funding

Development of a Preclinical Assay to Predict Efficacy of Ricin Toxin Subunit VaccinesR01AI125190 · NIAID · WADSWORTH CENTER · PI MANTIS, NICHOLAS J. · 2016 to 2020
$4.1M
NIAID NIH HHS HHSN272201400021CNIAID NIH HHS R01 AI125190
6 · The paper itself

Abstract

Ricin is a fast-acting protein toxin classified by the Centers for Disease Control and Prevention as a biothreat agent. In this report, we describe five new mouse mAbs directed against an immunodominant region, so-called epitope cluster II, on the surface of ricin's ribosome-inactivating enzymatic subunit A (RTA). The five mAbs were tested alongside four previously described cluster II-specific mAbs for their capacity to passively protect mice against 10× LD

Identifiers

PMID30766971
PMCPMC6372112
OpenAlexW2952519523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.