Apoferritin is maintaining the native conformation of citrate synthase

Yuri V Sergeev, Monika B Dolinska, J Fielding Hejtmancik

Abstract read

In one paragraph

Article in Journal of analytical & pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Toward structural-omics of the bovine retinal pigment epithelium.Cell reports · 2022
Article
The TYRP1-mediated protection of human tyrosinase activity does not involve stable interactions of tyrosinase domains.Pigment cell & melanoma research · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yuri V SergeevOphthalmic Genetics and Visual Function Branch, National Eye Institute, USA.

Monika B DolinskaOphthalmic Genetics and Visual Function Branch, National Eye Institute, USA.

J Fielding HejtmancikOphthalmic Genetics and Visual Function Branch, National Eye Institute, USA.

National Eye Institute · US

Funding

Clinical/molecular Studies In Families With Congenital Or Hereditary CataractsZIAEY000281 · NEI · NATIONAL EYE INSTITUTE · PI HEJTMANCIK, JAMES F. · 2009 to 2025

$18.1M

Proteins From Hereditary Eye Diseases: In-silico and Experimental StudiesZIAEY000476 · NEI · NATIONAL EYE INSTITUTE · PI SERGEEV, YURI · 2009 to 2025

$16.8M

Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA EY000476

6 · The paper itself

Abstract

Ferritin, a member of a family of iron storage proteins, is expressed in conditions of oxidative or thermal stress in the cell. Ferritin widely found in human tissues including the eye and brain. Increased expression under oxidative or temperature stress conditions and protective effect on cell viability suggest that apo form of ferritin (apoferritin) may have a role in the formation or maintenance of the native conformation of proteins. To test this hypothesis, we studied the influence of apoferritin on the unfolding and refolding of citrate synthase (CS)

Indexed as

apoferritinchaperoning-like propertyferritinmolecular crowdingprotection of protein catalytic activity

Identifiers

PMID30766967

PMCPMC6372109

OpenAlexW3020938208

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.