Evidence map›Paper›PMID 30766966›Full record

ArticleHepatology communications2019

Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018.

Jesus M Banales, Ariel E Feldstein, Hanna Sänger, Veronika Lukacs-Kornek, Gyongyi Szabo, Miroslaw Kornek

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Jesus M BanalesDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital University of the Basque Country, CIBERehd, Ikerbasque San Sebastian Spain.
Ariel E FeldsteinDivision of Pediatric Gastroenterology, Hepatology, and Nutrition University of California San Diego San Diego CA.
Hanna SängerDepartment of Medicine II, Saarland University Medical Center Saarland University Homburg Germany.
Veronika Lukacs-KornekInstitute of Experimental Immunology University Hospital of the Rheinische Friedrich-Wilhelms-University Bonn Germany.
Gyongyi SzaboDepartment of Medicine University of Massachusetts Medical School Worcester MA.
Miroslaw KornekDepartment of Oncology, Hematology and Rheumatology University Hospital Bonn Bonn Germany.
Ikerbasque · ESSaarland University · DEUniversity Hospital Bonn · DEUniversity of Bonn · DEUniversity of California San Diego · USUniversity of Massachusetts Chan Medical School · US

Funding

Alcohol and Monocyte Signaling Administrative SupplementR01AA011576 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gyongyi Szabo · 1998 to 2026
$9.3M
MicroRNAs in Alcoholic Liver Disease Administrative SupplementR01AA020744 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 2011 to 2023
$5.3M
Extracellular Vesicles in Alcoholic Liver Disease: Basic and Pre-Clinical DiscoveryUH3AA026970 · NIAAA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SZABO, GYONGYI · 2020 to 2022
$1.3M
Extracellular Vesicles in Alcoholic Liver Disease: Basic and Pre-Clinical DiscoveryUH2AA026970 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SZABO, GYONGYI · 2018 to 2019
$461k
NIAAA NIH HHS R01 AA011576NIAAA NIH HHS R01 AA020744NIAAA NIH HHS UH2 AA026970NIAAA NIH HHS UH3 AA026970
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are small and heterogeneous membrane-bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or distant target cells. EV cargo may reflect the cell of origin as well as the specific stress that induces their formation and release. They transport a variety of bioactive molecules, including messenger RNA, noncoding RNAs, proteins, lipids, and metabolites, that can be transferred among cells, regulating various cell responses. Alteration in the concentration and composition of EVs in biological fluids is a typical hallmark of pathologies in different liver diseases. Circulating EVs can serve as biomarkers or as messengers following uptake by other cells. This review is a meeting report from the International Liver Congress 2018 (European Association for the Study of the Liver) celebrated in Paris (Symposium: Extracellular vesicles and signal transmission) that discusses the role of EVs in several liver diseases, highlighting their potential value as disease biomarkers and therapeutic opportunities.

Identifiers

PMID30766966
PMCPMC6357829
OpenAlexW2907460015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.