IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. A systematic review examining the relationship between cytokines and cachexia in incurable cancer.Journal of cachexia, sarcopenia and muscle · 2022
   Pooled it
2. Pro-inflammatory cytokine-driven molecular signaling in skeletal muscle during cancer cachexia.Biochemical Society transactions · 2026
   Review
3. NF-κB Signaling as a Central Driver of Cancer Cachexia.Cancers · 2026
   Review
4. Effects of FermentedNutrients · 2024
   Article
5. Cancer-triggered systemic disease and therapeutic targets.Holistic integrative oncology · 2024
   Article
6. Development of skeletal muscle fibrosis in a rodent model of cancer cachexia.Cell biochemistry and function · 2023
   Article
7. Interleukin-6: A New Marker of Advanced-Sarcopenic HCC Cirrhotic Patients.Cancers · 2023
   Article
8. Association of Body Composition and Handgrip Strength with Interleukin-6 (IL-6) and Vitamin D Level in Cancer Patients.International journal of general medicine · 2023
   Article
9. Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation.Histochemistry and cell biology · 2022
   Review
10. Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production.International journal of molecular sciences · 2022
    Review
11. Shared and distinct mechanisms of skeletal muscle atrophy: A narrative review.Ageing research reviews · 2021
    Review
12. Sustained Systemic Levels of IL-6 Impinge Early Muscle Growth and Induce Muscle Atrophy and Wasting in Adulthood.Cells · 2021
    Article
13. The systemic pro-inflammatory response: targeting the dangerous liaison between COVID-19 and cancer.ESMO open · 2021
    Review
14. Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential role for cytokines such Is IL-6.Physiological research · 2021
    Review
15. Asprosin is associated with anorexia and body fat mass in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
16. Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.Journal of applied physiology (Bethesda, Md. : 1985) · 2021
    Article
17. Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19.International journal of molecular sciences · 2020
    Review
18. Adipose depot gene expression and intelectin-1 in the metabolic response to cancer and cachexia.Journal of cachexia, sarcopenia and muscle · 2020
    Article
19. Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications.In vivo (Athens, Greece) · 2020
    Review
20. Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer.Frontiers in cell and developmental biology · 2020
    Review

Corrections and comments

• Comment on
  Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.2016

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.