Evidence map›Paper›PMID 30766776›Full record

ReviewActa pharmaceutica Sinica. B2019

Adapting liposomes for oral drug delivery.

Haisheng He, Yi Lu, Jianping Qi, Quangang Zhu, Zhongjian Chen, Wei Wu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed.

  1. The oxidative stress paradigm in arbovirus infections: mechanisms and therapeutic insights.Redox report : communications in free radical research · 2026
    Review
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  7. Utilizing nanotechnology to diagnose and treat central nervous system disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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  20. Autophagy-Mediated Suppression of Tumor Growth by Food-Grade Lipid Nanoparticles in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haisheng HeKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China.
Yi LuKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China.
Jianping QiKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China.
Quangang ZhuShanghai Dermatology Hospital, Shanghai 200443, China.
Zhongjian ChenShanghai Dermatology Hospital, Shanghai 200443, China.
Wei WuKey Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.

Indexed as

AbsorptionAPC, antigen-presenting cellAUC, area under curveBioavailabilityBSA, bovine serum albuminDC, dendritic cellsDMPC, dimyristoyl phosphatidyl cholineDPPC, dipalmitoyl phosphotidylcholineDrug deliveryFAE, follicle-associated epitheliaFITC, fluorescein isothiocyannateGIT, gastrointestinal tractLiposomesLUV, large unilamellar vesiclesMLV, multilamellar vesiclesMRT, mean residence timeMVL, multivesicular liposomesOralPC, phosphatidylcholinePEG, polyethylene glycolRES, reticulo-endothelialrhEGF, recombinant human epithelial growth factorSC, sodium cholateSDC, sodium deoxycholateSGC, sodium glycocholateSPC, soy phosphatidylcholineStabilitySTC, sodium taurocholateSUV, small unilamellar vesiclesTgel, gelling temperatureTPGS, tocopherol polyethylene glycol succinateTp, phase transition temperatureUEA 1, ulex europaeus agglutinin 1WGA, wheat germ agglutinin

Identifiers

PMID30766776
PMCPMC6362257

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.