ArticleCancer biology & medicine2018
A new tumor-associated antigen prognostic scoring system for spontaneous ruptured hepatocellular carcinoma after partial hepatectomy.
Article in Cancer biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Research progress of spontaneous ruptured hepatocellular carcinoma: Systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Machine learning prediction of 30-day all-cause mortality risk factors in HCC rupture.Frontiers in oncology · 2026Article
- Article
- lncRNA Expression-Based Risk Scoring System Can Predict Survival of Tumor-Positive Patients with Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Treatment strategies and prognosis for initially unresectable ruptured hepatocellular carcinoma: a single-center experience in 94 patients.Diagnostic and interventional radiology (Ankara, Turkey) · 2020Article
- A novel nomogram to predict the local tumor progression after microwave ablation in patients with early-stage hepatocellular carcinoma: A tool in prediction of successful ablation.Cancer medicine · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSpontaneous hepatocellular carcinoma (HCC) rupture can be fatal, and hepatic resection could achieve a favorable long-term survival among all strategies of tumor rupture. However, there is no available prognostic scoring system for patients with ruptured HCC who underwent partial hepatectomy.
methodsFrom January 2005 to May 2015, 129 patients with spontaneous HCC rupture underwent partial hepatectomy. Preoperative clinical data were collected and analyzed. Independent risk factors affecting overall survival (OS) were used to develop the new scoring system. Harrell's C statistics, Akaike information criterion (AIC), the relative likelihood, and the log likelihood ratio were calculated to measure the homogeneity and discriminatory ability of a prognostic system.
resultsIn the multivariable Cox regression analysis, three factors, including tumor size, preoperative α-fetoprotein level, and alkaline phosphatase level, were chosen for the new tumor-associated antigen (TAA) prognostic scoring system. The 1-year OS rates were 88.1%, 43.2%, and 30.2% for TAA scores of 0-5 points (low-risk group), 6-9 points (moderate-risk group), and 10-13 points (high-risk group), respectively. The TAA scoring system had superior homogeneity and discriminatory ability (Harrell's C statistics, 0.693
conclusionsThe new prognostic scoring system is simple and effective in predicting both OS and DFS of patients with spontaneous ruptured HCC.
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