Evidence map›Paper›PMID 30766715›Full record

ArticleWomen's midlife health2018

Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Maria E Bleil, Paul English, Jhaqueline Valle, Nancy F Woods, Kyle D Crowder, Steven E Gregorich, Marcelle I Cedars

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Women's midlife health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria E Bleil1Department of Family and Child Nursing, University of Washington, Box 357262, Seattle, WA 98195 USA.
Paul EnglishCalifornia Department of Public Health, California Environmental Health Tracking Program, Richmond, CA 94804 USA.
Jhaqueline ValleCalifornia Department of Public Health, California Environmental Health Tracking Program, Richmond, CA 94804 USA.
Nancy F Woods3Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA 98195 USA.
Kyle D Crowder4Department of Sociology, University of Washington, Seattle, WA 98195 USA.
Steven E Gregorich5Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA.
Marcelle I Cedars6Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 USA.

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Genetic Epidemiology of Ovarian AgingR01HD044876 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CEDARS, MARCELLE IVONNE · 2005 to 2009
$6.6M
Psychosocial Factors in Reproductive AgingK08AG035375 · NIA · UNIVERSITY OF WASHINGTON · PI BLEIL, MARIA E. · 2009 to 2013
$598k
Impact of Life Course Socioeconomic Status on the Ovarian ReserveR03HD080893 · NICHD · UNIVERSITY OF WASHINGTON · PI BLEIL, MARIA E. · 2014 to 2015
$153k
NCRR NIH HHS UL1 RR024131NIA NIH HHS K08 AG035375NICHD NIH HHS R01 HD044876NICHD NIH HHS R03 HD080893
6 · The paper itself

Abstract

backgroundBecause the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring.

methodsIn a healthy, community-based sub-sample (

resultsIn separate covariate-adjusted linear regression models (following the backward elimination of main effects with

conclusionsMaternal socioeconomic disadvantage measured indirectly at the neighborhood level was associated with lower ovarian reserve among the adult offspring, independently of offspring SES and other potential confounding factors. This suggests SES-related adversity exposures may have a detrimental impact on the size or health of the initial follicle endowment, leading to accelerated follicle loss over time.

Indexed as

Antimullerian hormone (AMH)Antral follicle count (AFC)MenopauseNeighborhoodOvarian agingOvarian reservePovertySocioeconomic status (SES)

Identifiers

PMID30766715
PMCPMC6297989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.