Evidence map›Paper›PMID 30766706›Full record

ArticleWomen's midlife health2017

Anti-Müllerian hormone and its relationships with subclinical cardiovascular disease and renal disease in a longitudinal cohort study of women with type 1 diabetes.

Catherine Kim, Yuanyuan Pan, Barbara H Braffett, Valerie L Arends, Michael W Steffes, Hunter Wessells, Aruna V Sarma, DCCT/EDIC Research Group

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Women's midlife health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00360815 nacompletednot on this map

Diabetes Control and Complications Trial (DCCT)

TypeinterventionalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran1983 to 1993Enrolled1,441ConditionsType 1 Diabetes MellitusArmsInsulin
NCT00360893 active not recruitingnot on this map

Epidemiology of Diabetes Interventions and Complications (EDIC)

TypeobservationalSponsorGeorge Washington UniversityRan1994 to 2027Enrolled1,441ConditionsType 1 Diabetes Mellitus
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Catherine Kim1Departments of Medicine, Obstetrics & Gynecology, and Epidemiology, University of Michigan, 2800 Plymouth Road, Building 16, Room 430W, Ann Arbor, MI 48109-2800 USA.ORCID 0000-0001-9237-0532
Yuanyuan Pan2The Biostatistics Center, George Washington University, Rockville, MD USA.
Barbara H Braffett2The Biostatistics Center, George Washington University, Rockville, MD USA.
Valerie L Arends3Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN USA.
Michael W Steffes3Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN USA.
Hunter Wessells4Department of Urology, University of Washington, Seattle, WA USA.
Aruna V Sarma5Department of Urology, University of Michigan, Ann Arbor, MI USA.
DCCT/EDIC Research Group
George Washington University · USUniversity of Michigan · USUniversity of Minnesota · USUniversity of Washington · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Julie Mathieu · 1986 to 2026
$41.4M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
ReproEDIC: Risk and Progression of Reproductive Abnormalities in Type 1 DiabetesDP3DK098129 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, CATHERINE, SARMA, ARUNA V · 2013 to 2013
$803k
NIDDK NIH HHS DP3 DK098129NIDDK NIH HHS P30 DK017047NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

backgroundReproductive age may be a risk factor for vascular disease. Anti-Müllerian hormone (AMH) is produced by viable ovarian follicles and reflects reproductive age. We examined whether AMH concentrations were associated with markers of subclinical cardiovascular disease (CVD) and kidney disease among women with type 1 diabetes.

methodsWe performed a cross-sectional analysis of the Epidemiology of Diabetes Interventions and Complications Study

resultsAfter adjustment for age, AMH was not associated with waist circumference, blood pressure, lipid profiles, or renal function. Higher initial AMH concentrations had borderline but non-significant associations with the presence of CAC after adjustment for age (odds ratio [OR] 1.08, 95% confidence interval [CI] 1.00, 1.16) which were minimally altered by addition of other CVD risk factors, although women in the 3rd quartile of AMH had lower odds of CAC than women in the lowest quartile (OR 0.40, 95% CI 0.17, 0.94). After adjustment for age, higher AMH was associated with statistically significant but only slightly higher cIMT (0.005 mm,

conclusionsAmong midlife women with type 1 diabetes, AMH has slight but significant associations with subclinical measures of atherosclerosis. Future studies should examine whether these associations are clinically significant.

trial registrationNCT00360815 and NCT00360893 Study Start Date April 1994.

Indexed as

Anti-Müllerian hormoneCoronary artery calcificationOvarian reserveType 1 diabetes

Identifiers

PMID30766706
PMCPMC6299929
OpenAlexW2747546343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.