Evidence map›Paper›PMID 30766605›Full record

ArticleStem cells international2019

Environmental Benzopyrene Attenuates Stemness of Placenta-Derived Mesenchymal Stem Cells via Aryl Hydrocarbon Receptor.

June Seok Heo, Ja-Yun Lim, Sangshin Pyo, Dae Wui Yoon, Dongsook Lee, Wen Xiu Ren, Seung Gwan Lee, Gi Jin Kim, Jinkwan Kim

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

June Seok HeoDepartment of Integrated Biomedical and Life Sciences, College of Health Science, Korea University, Seoul 03722, Republic of Korea.
Ja-Yun LimDepartment of Integrated Biomedical and Life Sciences, College of Health Science, Korea University, Seoul 03722, Republic of Korea.
Sangshin PyoDepartment of Integrated Biomedical and Life Sciences, College of Health Science, Korea University, Seoul 03722, Republic of Korea.
Dae Wui YoonObstructive Upper Airway Research Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0001-8875-2255
Dongsook LeeDepartment of Integrated Biomedical and Life Sciences, College of Health Science, Korea University, Seoul 03722, Republic of Korea.
Wen Xiu RenDepartment of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province 400700, China.
Seung Gwan LeeDepartment of Health and Environmental Science, College of Health Science, Korea University, Seoul 03722, Republic of Korea.ORCID 0000-0001-5659-0044
Gi Jin KimDepartment of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea.ORCID 0000-0002-2320-7157
Jinkwan KimDepartment of Biomedical Laboratory Science, College of Health Science, Jungwon University, Chung-buk 28024, Republic of Korea.ORCID 0000-0002-7123-1354
Korea University · KRAffiliated Hospital of Southwest Medical University · CNCHA University · KRJungwon University · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The toxic effects of particulate matter have been linked to polycyclic aromatic hydrocarbons (PAHs) such as benzopyrene. PAHs are potent inducers of the aryl hydrocarbon receptor (AhR), which is an expressed nuclear receptor that senses environmental stimuli and modulates gene expression. Even though several studies have shown that the benzopyrene (BP) of chemical pollutants significantly impaired stem cell activity, the exact molecular mechanisms were not clearly elucidated. In the present study, we aimed to investigate the effects of BP on placenta-derived mesenchymal stem cells (PD-MSCs)

Identifiers

PMID30766605
PMCPMC6350590
OpenAlexW2909916084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.