ArticleAfrican health sciences2018
Interferon-γ receptor-1 gene promoter polymorphisms and susceptibility for brucellosis in Makkah region.
Article in African health sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat.Irish veterinary journal · 2025Article
- A Mini-review onEndocrine, metabolic & immune disorders drug targets · 2024Review
- The Effect of Erythritol Injection in Decreasing of Abortion Rate in Local Breed Ewes.Veterinary medicine international · 2023Article
- Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer.Journal of gastrointestinal cancer · 2021Review
- Interface of non-communicable diseases and infections in Africa.African health sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic polymorphisms that affect the production levels of certain cytokines and/or their receptors may determine the risk, severity or protection in some infectious diseases like brucellosis.
objectivesThe aim of this study was to investigate the association of certain known Interferon-γ Receptor-1 (IFN-γ R1) gene promoter polymorphisms and the susceptibility to infection with Brucellosis in Saudi population.
methodsA cases-control association study was conducted in 69 individuals with human brucellosis and 94 healthy individuals. Genotyping of IFN-γ R1 - 56 C>T and IFN-γ R1 - 611 A>G polymorphism in both patients and healthy controls was done by PCR- restriction enzyme length polymorphisms (PCR-RFLP) and PCR- confronting two primer pairs (PCR-CTPP) methods and were assessed for potential associations with susceptibility for human brucellosis and their mode of penetrance.
resultsInterestingly, we have designed a PCR-CTPP system to be used for genotyping of IFN-γ R1 - 611 A > G polymorphism. The PCR-CTPP is an accurate method for genotyping of SNPs. Moreover, it is time-saving, inexpensive and easy to perform.
conclusionBoth tested polymorphisms, IFN-γ R1 - 56 C>T and IFN-γ R1 -611 A>G polymorphism had no role in genetic susceptibility to human brucellosis in the study population. The PCR-CTPP can be used for genotyping IFN-γ R1 - 611 A > G polymorphism and other types of mutation.
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