Evidence map›Paper›PMID 30766536›Full record

ArticleFrontiers in immunology2019

CD11c

Adam M Sandor, Robin S Lindsay, Nathan Dyjack, Jennifer C Whitesell, Cydney Rios, Brenda J Bradley, Kathryn Haskins, David V Serreze, Aron M Geurts, Yi-Guang Chen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

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  13. Self-Renewing Islet TCF1Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Adam M SandorDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Robin S LindsayDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Nathan DyjackCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, United States.
Jennifer C WhitesellDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Cydney RiosCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, United States.
Brenda J BradleyDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Kathryn HaskinsDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
David V SerrezeThe Jackson Laboratory, Bar Harbor, ME, United States.
Aron M GeurtsDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Yi-Guang ChenDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Max A SeiboldCenter for Genes, Environment, and Health, National Jewish Health, Denver, CO, United States.
Jordan JacobelliDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Rachel S FriedmanDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
National Jewish Health · USUniversity of Colorado Anschutz Medical Campus · USMedical College of Wisconsin · USJackson Laboratory · USUniversity of Colorado Denver · US

Funding

The Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI LUTZ, CATHLEEN M · 2015 to 2019
$10.2M
Transcriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI VOELKER, DENNIS R. · 2017 to 2021
$9.0M
Diabetogenic Role of MHC Class I Alleles in NOD MiceR01DK046266 · NIDDK · JACKSON LABORATORY · PI SERREZE, DAVID V · 2000 to 2018
$7.2M
B-lymphocyte Targeting Therapies for Autoimmune DiabetesR01DK095735 · NIDDK · JACKSON LABORATORY · PI SERREZE, DAVID V · 2013 to 2025
$6.2M
Mechanistic and Therapeutic Role of the CD137-CD137L Axis in Type 1 DiabetesR01DK107541 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG, RIDGWAY, WILLIAM M · 2016 to 2025
$5.6M
Discovery and Functional Studies of Genes for T1D GWAS Susceptibility LociDP3DK097605 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG, GEURTS, ARON M · 2012 to 2012
$4.3M
MerTK Mediated T Cell Suppression in the Pancreatic Islets During Type 1 DiabetesR01DK111733 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Rachel S Friedman · 2017 to 2026
$4.1M
Role of Formins in Islet Infiltration in Type 1 DiabetesR21AI119932 · NIAID · NATIONAL JEWISH HEALTH · PI FRIEDMAN, RACHEL S · 2015 to 2016
$436k
NHLBI NIH HHS P01 HL132821NIAID NIH HHS R21 AI119932NIDDK NIH HHS DP3 DK097605NIDDK NIH HHS R01 DK046266NIDDK NIH HHS R01 DK095735NIDDK NIH HHS R01 DK107541NIDDK NIH HHS R01 DK111733NIH HHS U54 OD020351
6 · The paper itself

Abstract

Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through the islet vasculature. Understanding the cues that lead to T cell entry into inflamed islets is important because diagnosed T1D patients already have established immune infiltration of their islets. Here we show that CD11c

Indexed as

AnimalsCD11c AntigenDiabetes Mellitus, Type 1FemaleIslets of LangerhansMice, Inbred NODMice, KnockoutT-LymphocytesCD11c AntigenCD11c+ cellschemokineextravasationlymphocyte traffickingmononuclear phagocyte cellsT celltype 1 diabetes

Identifiers

PMID30766536
PMCPMC6365440
OpenAlexW2913314727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.