Evidence map›Paper›PMID 30766429›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2019

Ariadna Lafourcade Prada, Hady Keita, Tatiane Pereira de Souza, Emerson Silva Lima, Leonard Domingo Rosales Acho, Márcia de Jesus Amazonas da Silva, José Carlos Tavares Carvalho, Jesus Rafael Rodriguez Amado

Open access · hybridAbstract read
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ariadna Lafourcade PradaPharmacy Department, Faculty of Natural Sciences, University of Oriente, Patricio Lumumba s/n, Santiago de Cuba, CP 84500 Santiago de Cuba, Cuba.
Hady KeitaDivision of Postgraduate Studies in Health, University of La Sierra del Sur, Calle Guillermo Rojas Mijangos S/N, Esq. Av. Universidad Colonial, Miahuatlán de Porfirio Díaz, C.P. 70800 Oaxaca, Mexico.
Tatiane Pereira de SouzaLaboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Ave Rodrigo Otavio Ramos, 6200, Barrio Coroado, CEP 69077-000 Manaus, AM, Brazil.
Emerson Silva LimaLaboratory of Biological Activity, Pharmaceutical Sciences Faculty, Federal University of Amazonas, Ave. Rodrigo Otavio Ramos 6200, Coroado, CEP 69077-000 Manaus, AM, Brazil.
Leonard Domingo Rosales AchoLaboratory of Biological Activity, Pharmaceutical Sciences Faculty, Federal University of Amazonas, Ave. Rodrigo Otavio Ramos 6200, Coroado, CEP 69077-000 Manaus, AM, Brazil.
Márcia de Jesus Amazonas da SilvaLaboratory of Biological Activity, Pharmaceutical Sciences Faculty, Federal University of Amazonas, Ave. Rodrigo Otavio Ramos 6200, Coroado, CEP 69077-000 Manaus, AM, Brazil.
José Carlos Tavares CarvalhoDrug Research Laboratory, Federal University of Amapá, Rodovia Juscelino Kubitschek, km 2, Jardim Marco Zero, CEP: 68903-419 Macapá, AP, Brazil.
Jesus Rafael Rodriguez AmadoPharmacy Department, Faculty of Natural Sciences, University of Oriente, Patricio Lumumba s/n, Santiago de Cuba, CP 84500 Santiago de Cuba, Cuba.
Universidade Federal do Amazonas · BRUniversidad de la Sierra · MXUniversidad de Oriente · CUUniversidade Federal do Amapá · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the hypoglycemic effect, antioxidant, α-glucosidase and lipase inhibitory activity, and the cytotoxicity of the

methodsThe hypoglycemic effect was evaluated in alloxan-induced diabetic mice. The particle size, polydispersion index, ζ-potential, and conductivity, as well as the drug-loaded content, were monitored in shelf-live, along a year. The delivery profile was evaluated in simulated intestinal fluids at pH 6.5 and 7.4. The antioxidant effect was evaluated as DPPH and ABTS inhibition. The murine α-glucosidase inhibitory activity and the lipase-inhibitory effect were evaluated

resultsCgND remained stable for a year in shelf conditions. The hypoglycemic effect in a dose of 10 mg/kg was not statistically different from glibenclamide 25 mg/kg. Nanoparticles released 100% of extract in 120 min at pH 6.5 and 7.4. Nanodispersion exhibited a potent α-glucosidase and lipase-inhibitory effect with IC

Indexed as

Alpha-glucosidaseAntioxidantCassia grandisHypoglycemicLipase inhibitoryNanodispersion

Identifiers

PMID30766429
PMCPMC6362179
OpenAlexW2896410306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.