ArticleInternational journal of obesity (2005)2020
Does birth mode modify associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome?
Article in International journal of obesity (2005), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- The effect of gestational weight gain on the infant gut microbiome- a systematic review of the literature.Frontiers in cellular and infection microbiology · 2026Pooled it
- Maternal gut microbiota in the postpartum Period: A Systematic review.European journal of obstetrics, gynecology, and reproductive biology · 2023Pooled it
- Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.Gut microbesPooled it
- Associations between maternal obesity and offspring gut microbiome in the first year of life.Pediatric obesity · 2022Trial
- ACMTF-R: Supervised multi-omics data integration uncovering shared and distinct outcome-associated variation.PloS one · 2026Article
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV.Current HIV/AIDS reports · 2025Review
- Interaction between the breast tumor microenvironment and gut microbiome.Gut microbes · 2025Review
- Multiple perinatal characteristics affect the association between maternal diabetes status and early neonatal gut microbiota.mSphere · 2025Article
- Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies.Genomics, proteomics & bioinformatics · 2024Review
- Article
- Maternal oral probiotic use is associated with decreased breastmilk inflammatory markers, infant fecal microbiome variation, and altered recognition memory responses in infants-a pilot observational study.Frontiers in nutrition · 2024Article
- Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age.PLoS biology · 2023Article
- Sources of gut microbiota variation in a large longitudinal Finnish infant cohort.EBioMedicine · 2023Article
- Maternal Nutritional Status and the Microbiome across the Pregnancy and the Post-Partum Period.Microorganisms · 2023Review
- Review
- Early life adverse exposures in irritable bowel syndrome: new insights and opportunities.Frontiers in pediatrics · 2023Review
- Assessing the impact of pregnancy and birth factors on the maternal and infant microbiota.Microbiome research reports · 2023Article
- Maternal dietary fiber intake during pregnancy and child development: the Japan Environment and Children's Study.Frontiers in nutrition · 2023Article
- Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis.Cancer reports (Hoboken, N.J.) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMother-to-newborn transmission of obesity-associated microbiota may be modified by birth mode (vaginal vs. Cesarean delivery). Prospective data to test this hypothesis are still sparse.
objectiveTo examine prospective associations of maternal pre-pregnancy BMI and gestational weight gain with the infant gut microbiome by birth-mode strata. SUBJECTS/
methodsIn 335 mother-infant pairs in the New Hampshire Birth Cohort, we ascertained data from questionnaires and medical records, and generated microbiome data from 6-week-old infants' stool using Illumina 16s rRNA gene sequencing (V4-V5 region). Analyses were stratified by birth mode and conducted before and after adjusting for potential confounders, which included maternal age, education, parity, and Mediterranean diet score.
resultsAmong 335 mothers, 56% had normal pre-pregnancy BMI ( < 25, referent), 27% were overweight (BMI 25-30), and 18% obese (BMI > 30). Among the 312 mothers with weight gain data, 10% had inadequate weight gain, 30% adequate (referent), and 60% excess. Birth mode modified associations of pre-pregnancy BMI with several genera, including the most abundant genus, Bacteroides (P for interaction = 0.05). In the vaginal-delivery group, maternal overweight or obesity was associated with higher infant gut microbiome diversity and higher relative abundance of 15 operational taxonomic units (OTUs), including overrepresentation of Bacteroides fragilis, Escherichia coli, Veillonella dispar, and OTUs in the genera Staphylococcus and Enterococcus. In the Cesarean-delivered group, there were no significant associations of pre-pregnancy BMI with infant microbiome (alpha) diversity or OTUs. Gestational weight gain was not associated with differential relative abundance of infant gut microbial OTUs or with measures of microbial diversity in infants delivered vaginally or by Cesarean section.
conclusionsAmong vaginally-delivered infants, maternal overweight and obesity was associated with altered infant gut microbiome composition and higher diversity. These associations were not observed in Cesarean-delivered infants, whose microbiome development differs from vaginally-delivered infants. Our study provides additional evidence of birth-mode dependent associations of maternal body weight status with the infant gut microbiota. The role of these associations in mediating the intergenerational cycle of obesity warrants further examination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.