ArticleScientific reports2019
Structural and molecular correlates of cognitive aging in the rat.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
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- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
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- Angiotensin II-Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Age-related changes in the primary auditory cortex of newborn, adults and aging bottlenose dolphins (Frontiers in neuroanatomy · 2023Article
- Cortex-specific transcriptome profiling reveals upregulation of interferon-regulated genes after deeper cerebral hypoperfusion in mice.Frontiers in physiology · 2023Article
- Altered PVN-to-CA2 hippocampal oxytocin pathway and reduced number of oxytocin-receptor expressing astrocytes in heart failure rats.Journal of neuroendocrinology · 2022Article
- Lifespan extension with preservation of hippocampal function in aged system xMolecular psychiatry · 2022Article
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- Vangl2, a Core Component of the WNT/PCP Pathway, Regulates Adult Hippocampal Neurogenesis and Age-Related Decline in Cognitive Flexibility.Frontiers in aging neuroscience · 2022Article
- Estradiol promotes and progesterone reduces anxiety-like behavior produced by nicotine withdrawal in female rats.Psychoneuroendocrinology · 2020Article
- Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging.Aging cell · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Aging is associated with cognitive decline. Herein, we studied a large cohort of old age and young adult male rats and confirmed that, as a group, old rats display poorer spatial learning and behavioral flexibility than younger adults. Surprisingly, when animals were clustered as good and bad performers, our data revealed that while in younger animals better cognitive performance was associated with longer dendritic trees and increased levels of synaptic markers in the hippocampus and prefrontal cortex, the opposite was found in the older group, in which better performance was associated with shorter dendrites and lower levels of synaptic markers. Additionally, in old, but not young individuals, worse performance correlated with increased levels of BDNF and the autophagy substrate p62, but decreased levels of the autophagy complex protein LC3. In summary, while for younger individuals "bigger is better", "smaller is better" is a more appropriate aphorism for older subjects.
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