Evidence map›Paper›PMID 30765859›Full record

ArticleScientific reports2019

Stress-induced mast cell activation contributes to atherosclerotic plaque destabilization.

H Maxime Lagraauw, Anouk Wezel, Daniël van der Velden, Johan Kuiper, Ilze Bot

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  16. Vascular Diseases and Gangliosides.International journal of molecular sciences · 2019
    Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

H Maxime LagraauwDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Anouk WezelDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Daniël van der VeldenDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Johan KuiperDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Ilze BotDivision of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. i.bot@lacdr.leidenuniv.nl.ORCID 0000-0002-1242-1959

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cells accumulate in the perivascular tissue during atherosclerotic plaque progression and contribute to plaque destabilization. However, the specific triggers for mast cell activation in atherosclerosis remain unresolved. We hypothesized that psychological stress-induced activation of mast cells may contribute to plaque destabilization. To investigate this, apoE

Indexed as

Stress, PhysiologicalAnimalsDiet, High-FatDisease ProgressionMaleMast CellsMiceMice, Knockout, ApoEPlaque, Atherosclerotic

Identifiers

PMID30765859
PMCPMC6375972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.