ArticleScientific reports2019
Integrated analysis of mRNAs and long noncoding RNAs in the semen from Holstein bulls with high and low sperm motility.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Current Applications and Future Prospects of High-ThroughputAnimals : an open access journal from MDPI · 2026Review
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- Dissecting genomes of multiple yak populations: unveiling ancestry and high-altitude adaptation through whole-genome resequencing analysis.BMC genomics · 2025Article
- Comparative gene expression profiling of fertility related transcripts in bull sperm of different genetic backgrounds.Tropical animal health and production · 2025Article
- Exploring the Characters of Non-Coding RNAs in Spermatogenesis and Male Infertility.International journal of molecular sciences · 2025Review
- Identification of reproductive performance in Bali-polled bulls using computer-assisted semen analysis and plasma seminal proteomics.Veterinary world · 2025Article
- Development and optimization of an efficient RNA isolation protocol from bovine (Biochemistry and biophysics reports · 2024Article
- Single Sperm RNA signatures reveal MicroRNA biomarkers for male subfertility.Journal of assisted reproduction and genetics · 2024Article
- MicroRNAs and Their Associated Genes Regulating the Acrosome Reaction in Sperm of High- versus Low-Fertility Holstein Bulls.Animals : an open access journal from MDPI · 2024Article
- Sperm long non-coding RNAs as markers for ram fertility.Frontiers in veterinary science · 2024Article
- Coordinated alternation of DNA methylation and alternative splicing of PBRM1 affect bovine sperm structure and motility.Epigenetics · 2023Article
- Development and validation of most efficient RNA isolation method from buffalo bull spermatozoa.Molecular biology reports · 2023Article
- QTLs and Candidate Genes Associated with Semen Traits in Merino Sheep.Animals : an open access journal from MDPI · 2023Article
- Harnessing male germline epigenomics for the genetic improvement in cattle.Journal of animal science and biotechnology · 2023Review
- Integrating sperm cell transcriptome and seminal plasma metabolome to analyze the molecular regulatory mechanism of sperm motility in Holstein stud bulls.Journal of animal science · 2023Article
- Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight.Frontiers in endocrinology · 2023Review
- Sperm Transcriptome Analysis Accurately Reveals Male Fertility Potential in Livestock.Animals : an open access journal from MDPI · 2022Review
- Developmental RNA-Seq transcriptomics of haploid germ cells and spermatozoa uncovers novel pathways associated with teleost spermiogenesis.Scientific reports · 2022Article
- LncRNAs in domesticated animals: from dog to livestock species.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm motility is the main index used to assess the quality of bull semen. It may also be used to evaluate the fertility potential of bulls. Protein-coding mRNA and long noncoding RNA (lncRNA) participate in the regulation of spermatogenesis. Here, we employed strand-specific RNA sequencing to profile the semen transcriptome (mRNA and lncRNA) of six paired full-sibling Holstein bulls with divergent sperm motility and to determine the functions of mRNA and lncRNA in sperm motility. Among 20,875 protein-encoding genes detected in semen, 19 were differentially expressed between the high sperm motility group (H: H1, H2, and H3) and low sperm motility group (L: L1, L2, and L3). Of the 11,561 lncRNAs identified in sperm, 2,517 were differentially expressed between the H and L groups. We found that TCONS_00041733 lncRNA targets the node gene EFNA1 (ephrin A1), involved in male reproductive physiology. Our study provides a global mRNA and lncRNA transcriptome of bull semen, as well as novel insights into the regulation of neighboring protein coding by lncRNAs and the influence of mRNAs on sperm motility.
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