ArticleScientific reports2019
Anterior cingulate GABA and glutamate concentrations are associated with resting-state network connectivity.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Acute neural effects of the mood stabiliser lamotrigine on emotional processing in healthy volunteers: a randomised control trial.Translational psychiatry · 2024Trial
- Effects of NMDA-receptor blockade by ketamine on mentalizing and its neural correlates in humans: a randomized control trial.Scientific reports · 2023Trial
- Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are associated with anterior cingulate GABA.Cerebral cortex (New York, N.Y. : 1991) · 2023Trial
- Greater Somatosensory Afference With Acupuncture Increases Primary Somatosensory Connectivity and Alleviates Fibromyalgia Pain via Insular γ-Aminobutyric Acid: A Randomized Neuroimaging Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2021Trial
- The association among glutamate, GABA, and anterior cingulate connectivity in schizophrenia spectrum disorders: Implications for symptom domains.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- In Vivo Glx Measurements From GABA-Edited HERMES at 3 T Are Not Consistent With Those From Short-TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups.NMR in biomedicine · 2026Article
- Real-time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects: study protocol for a randomized controlled trial in individuals at clinical high risk.BMC psychiatry · 2025Article
- Regional Excitatory-Inhibitory Balance Relates to Self-Reference Effect on Recollection via the Precuneus/Posterior Cingulate Cortex-Medial Prefrontal Cortex Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns.Frontiers in computational neuroscience · 2025Article
- Rebalance the Inhibitory System in the Elderly Brain: Influence of Balance Learning on GABAergic Inhibition and Functional Connectivity.Human brain mapping · 2024Article
- GABA (gamma-aminobutyric acid) levels in dorsal anterior cingulate cortex are negatively associated with food motivation in a pediatric sample.Scientific reports · 2024Article
- Recurrent inhibition refines mental templates to optimize perceptual decisions.Science advances · 2024Article
- Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer's Disease.Translational neurodegeneration · 2024Review
- Neurobiological alteration in agitation in Alzheimer's disease and possible interventions.Frontiers in psychiatry · 2024Article
- Gamma neuromodulation improves episodic memory and its associated network in amnestic mild cognitive impairment: a pilot study.Neurobiology of aging · 2023Article
- Gamma-Aminobutyric Acid and Glutamate Concentrations in the Striatum and Anterior Cingulate Cortex Not Found to Be Associated with Cognitive Flexibility.Brain sciences · 2023Article
- Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making.PLoS biology · 2023Article
- GABAFrontiers in neuroscience · 2023Article
- Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex.Neurobiology of stress · 2022Article
- Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, resting-state (RS) networks and RS function have received increased attention, highlighting their importance in both cognitive function and psychopathology. The neurochemical substrates underlying RS networks and their interactions, however, have not yet been well established. Even though prior research has provided first evidence for a negative association between brain GABA levels and RS connectivity, these findings have been limited to within network connectivity, and not network interactions. In this multi-modal imaging study, we investigated the role of the main inhibitory neurotransmitter У-aminobutyric acid (GABA) and the main excitatory neurotransmitter glutamate (Glx) on RS network function and network coupling of three core networks: the default-mode network (DMN), salience network (SN), and central executive network (CEN). Resting-state functional connectivity and GABA and Glx levels in the dorsal anterior cingulate cortex (dACC) were assessed in 64 healthy male participants using functional MRI and magnetic resonance spectroscopy (MRS). Analyses showed that dACC GABA levels were positively correlated with resting-state connectivity in the CEN, and negatively associated with functional coupling of the DMN and CEN. In contrast, GABA/Glx ratios were inversely correlated with the SN and DMN. These findings extend insights into the role of GABA and Glx in individual networks to interactions across networks, suggesting that GABA levels in the SN might play a role in RS functional connectivity within the central executive network, and network interactions with the default-mode network. Our results further suggest a potentially critical role of the relationship between GABA and Glx in RS network function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.