Evidence map›Paper›PMID 30765785›Full record

SynthesisScientific reports2019

Silver diamine fluoride versus sodium fluoride for arresting dentine caries in children: a systematic review and meta-analysis.

Alice Trieu, Ahmed Mohamed, Edward Lynch

Registry-linked trialOpen access · goldAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07153328 (Silver Diamine Fluoride in Arresting Dental Caries Among Young Children, a Randomized Clinical Trial), which is not on this map. Cited by 35 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 6 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07153328 nacompletednot on this mapstarted 2021, after this paper: background citation

Silver Diamine Fluoride in Arresting Dental Caries Among Young Children, a Randomized Clinical Trial

TypeinterventionalSponsorBeaty DentRan2021 to 2024Enrolled104ConditionsDental CariesArmsSilver Diamine Fluoride (SDF, 38%) and Sodium Fluoride Varnish (NaF, 5%), Silver Diamine Fluoride (SDF, 38%)
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021
    Trial
  10. Silver diamine fluoride for non-operative restorative treatment and prevention of dental caries.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Effects of Tooth Desensitizers onInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alice TrieuPediatric Dental Resident, Pediatric Dentistry Department, University of Nevada, Las Vegas (UNLV), 89106, USA.
Ahmed MohamedVisiting Faculty, Biomedical and Clinical Research, University of Nevada, Las Vegas (UNLV), 89106, USA.
Edward LynchProfessor and Principal Director of Biomedical and Clinical Research, University of Nevada, Las Vegas (UNLV), 89106, USA. edward.lynch@unlv.edu.
University of Nevada, Las Vegas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental caries can compromise quality of life and is associated with demineralization of tooth structure by organic acids produced by microorganisms. This study systematically reviewed the dentine caries arrest capabilities of silver diamine fluoride (SDF) and sodium fluoride (NaF). A comprehensive search strategy was developed to identify the relevant publications in electronic databases and hand searched journals and reviews (to March 2018). By applying strict inclusion and exclusion criteria, only six papers (two randomized controlled trials, two follow-up articles and two secondary statistical analysis studies) were considered for full text qualitative and quantitative assessment. The included studies were critically appraised and statistically evaluated. Only four articles were considered for meta-analysis, as the other two were secondary analyses of included studies. When comparing the caries arrest lesions of SDF and NaF, SDF was found to be statistically more effective in dentine caries arrest of primary teeth during the 18 and 30 month clinical examinations. The weighted total effect size of the differences between SDF and NaF regarding arrested caries surfaces was calculated and showed nearly double the effectiveness of SDF to NaF at 30 months. Therefore, SDF is a more effective caries management reagent than NaF. Further clinical research is needed to consolidate the findings of this systematic review.

Indexed as

Cariostatic AgentsChildDental CariesFluorides, TopicalHumansPrognosisQuaternary Ammonium CompoundsSilver CompoundsSodium FluorideCariostatic AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideSodium Fluoride

Identifiers

PMID30765785
PMCPMC6376061
OpenAlexW2924110392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.