ArticleScientific reports2019
Serotonin Transporter Deficiency is Associated with Dysbiosis and Changes in Metabolic Function of the Mouse Intestinal Microbiome.
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Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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35 citing papers in PubMed, 65 citations in OpenAlex.
- The effect of SSRI/SNRI antidepressant treatment on the gut microbiota of patients with major depressive disorder.Communications medicine · 2026Article
- Crosstalk Between Gut Microbiota, Epigenome, and Neurotransmitters in Health and Disease.Cells · 2026Review
- Gut dysbiosis leads to cognitive decline through CNTF-mediated activation of microglia in mice.BMC biology · 2025Article
- The Role of Solute Carrier Family Transporters in Hepatic Steatosis and Hepatic Fibrosis.Journal of clinical and translational hepatology · 2025Review
- The emerging role of gut hormones.Molecules and cells · 2024Review
- Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa.International journal of molecular sciences · 2024Article
- Chronic intestinal pseudo-obstruction: associations with gut microbiota and genes expression of intestinal serotonergic pathway.BMC microbiology · 2024Article
- Emerging Roles of Gut Serotonin in Regulation of Immune Response, Microbiota Composition and Intestinal Inflammation.Journal of the Canadian Association of Gastroenterology · 2024Review
- Molecular Mechanisms of Reelin in the Enteric Nervous System and the Microbiota-Gut-Brain Axis: Implications for Depression and Antidepressant Therapy.International journal of molecular sciences · 2024Review
- Host-gut microbiota interactions during pregnancy.Evolution, medicine, and public health · 2024Review
- Cocaine hydrochloride, cocaine methiodide and methylenedioxypyrovalerone (MDPV) cause distinct alterations in the structure and composition of the gut microbiota.Scientific reports · 2023Article
- Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives.Microorganisms · 2023Review
- Serotonin Transporter (SERT) Expression Modulates the Composition of the Western-Diet-Induced Microbiota in Aged Female Mice.Nutrients · 2023Article
- Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.Molecular brain · 2023Article
- Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding.Frontiers in immunology · 2023Article
- Analysis of the therapeutic effect of Dimu Ningshen (TCM formula) on attention deficit hyperactivity disorder based on gut microbiota and serum metabolomics.BMC complementary medicine and therapies · 2022Article
- Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?Microorganisms · 2021Review
- Effect of Akkermansia muciniphila, Faecalibacterium prausnitzii, and Their Extracellular Vesicles on the Serotonin System in Intestinal Epithelial Cells.Probiotics and antimicrobial proteins · 2021Article
- Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment.Microorganisms · 2021Review
- Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
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Authors and funding
12 authors at 1 institution in 1 country.
Megha SinghalDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA.
Benjamin A TurturiceDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA.ORCID 0000-0001-9382-4612
Christopher R ManzellaDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, USA.
Ravi RanjanDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA.
Ahmed A MetwallyDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA.
Juliana TheorellDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA.
Yue HuangDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA.
Waddah A AlrefaiDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA.
Pradeep K DudejaDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA.
Patricia W FinnDivision of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA.
David L PerkinsDivision of Nephrology, University of Illinois at Chicago, Chicago, USA.
Ravinder K GillDivision of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA. rgill@uic.edu.
University of Illinois Chicago · US
Funding
Intestinal Anion Transporters: Function and RegulationR01DK054016 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 1998 to 2022
$7.0MEpidemiology of the gut microbiome, prediabetes and diabetes in LatinosR01MD011389 · NIMHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BURK, ROBERT D, KAPLAN, ROBERT C · 2016 to 2020
$4.3MPrecision Medicine in SarcoidosisR01HL138628 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JACOBSON, JEFFREY R, PERKINS, DAVID LINN · 2018 to 2021
$3.6MTransporter Trafficking Mechanisms in Infectious DiarrheaR01DK092441 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2011 to 2020
$3.0MIntestinal 5-HT Transporter: A novel therapeutic target for GI disordersR01DK098170 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GILL, RAVINDER K · 2014 to 2022
$3.0MProbiotics:Potential Therapeutic Roles in DiarrheaR01DK081858 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2008 to 2017
$2.5MRegulation of Intestinal Bile Acid TransportR01DK071596 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALREFAI, WADDAH A. · 2005 to 2014
$2.3MThe microbiota and allograft rejection: novel investigations into the consequences of obesityU01AI132898 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEGRE, MARIA-LUISA, PERKINS, DAVID LINN · 2017 to 2021
$2.3MGut-liver crosstalk in bile-acid induced diarrheaR01DK109709 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALREFAI, WADDAH A. · 2016 to 2019
$1.1MNovel role of serotonin in AhR dependent pathways in intestineF30DK113703 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MANZELLA, CHRISTOPHER ROBERT · 2017 to 2020
$199kPerinatal Origins of AsthmaF30HL136001 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TURTURICE, BENJAMIN · 2017 to 2020
$192kMechanisms of Regulation of Intestinal Cl Absorption in IBD Associated DiarrheaI01BX002011 · VA · JESSE BROWN VA MEDICAL CENTER · PI DUDEJA, PRADEEP K · 2013 to 2024
–BLRD VA I01 BX000152BLRD VA I01 BX002011BLRD VA IK6 BX005243NHLBI NIH HHS F30 HL136001NHLBI NIH HHS R01 HL138628NIAID NIH HHS U01 AI132898NIDDK NIH HHS F30 DK113703NIDDK NIH HHS R01 DK054016NIDDK NIH HHS R01 DK071596NIDDK NIH HHS R01 DK081858NIDDK NIH HHS R01 DK092441NIDDK NIH HHS R01 DK098170NIDDK NIH HHS R01 DK109709NIMHD NIH HHS R01 MD011389
Abstract
Serotonin transporter (SERT) plays a critical role in regulating extracellular availability of serotonin (5-HT) in the gut and brain. Mice with deletion of SERT develop metabolic syndrome as they age. Changes in the gut microbiota are being increasingly implicated in Metabolic Syndrome and Diabetes. To investigate the relationship between the gut microbiome and SERT, this study assessed the fecal and cecal microbiome profile of 11 to 12 week-old SERT
Indexed as
Gastrointestinal MicrobiomeGene Expression RegulationAnimalsBacteriaDysbiosisFecesMetagenomicsMiceMice, Inbred C57BLMice, KnockoutRNA, Ribosomal, 16SSerotonin Plasma Membrane Transport ProteinsRNA, Ribosomal, 16SSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.