ArticleScientific reports2019
Electroceutical Treatment of Pseudomonas aeruginosa Biofilms.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- A Prospective, Randomized, Controlled Study to Evaluate the Effectiveness of a Fabric-Based Wireless Electroceutical Dressing Compared to Standard-of-Care Treatment Against Acute Trauma and Burn Wound Biofilm Infection.Advances in wound care · 2024Trial
- The impact of pelvic floor electrical stimulation on vaginal microbiota and immunity.Frontiers in cellular and infection microbiology · 2022Trial
- Effects of Lysozyme and Silver Anode Treatment on Pseudomonas aeruginosa Growth and Biofilm Formation in Raw Milk.Journal of food science · 2026Article
- Adjunctive intraoperative pulsed direct current with cefazolin: a rabbit proof-of-concept model for prevention of prosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
- Sensing the Reducing Power to Determine the Cell Fate: Flavin Redox-Switches in Signal Transduction.Current microbiology · 2025Review
- Article
- Antifungal Activity, Synergism with Fluconazole or Amphotericin B and Potential Mechanism of Direct Current againstAntibiotics (Basel, Switzerland) · 2024Article
- Killing of a Multispecies Biofilm Using Gram-Negative and Gram-Positive Targeted Antibiotic Released from High Purity Calcium Sulfate Beads.Microorganisms · 2023Article
- Recent Advances in Functional Wound Dressings.Advances in wound care · 2023Review
- Swine Model of Biofilm Infection and Invisible Wounds.Journal of visualized experiments : JoVE · 2023Article
- Differential metabolism between biofilm and suspended Pseudomonas aeruginosa cultures in bovine synovial fluid by 2D NMR-based metabolomics.Scientific reports · 2022Article
- Electrochemical Sensors Based on MoSAdvanced healthcare materials · 2022Article
- Electroceutical treatment of infected chronic wounds in a dog and a cat.Veterinary surgery : VS · 2022Article
- Exploration of the Pharmacodynamics for Pseudomonas aeruginosa Biofilm Eradication by Tobramycin.Antimicrobial agents and chemotherapy · 2022Article
- Cadaverine Is a Switch in the Lysine Degradation Pathway inFrontiers in cellular and infection microbiology · 2022Article
- Mechanisms and Control Strategies of Antibiotic Resistance in Pathological Biofilms.Journal of microbiology and biotechnology · 2021Review
- Printed Electroceutical Dressings for the Inhibition of Biofilms and Treatment of Chronic Wounds.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2020Article
- Ultrastructure imaging of Pseudomonas aeruginosa lawn biofilms and eradication of the tobramycin-resistant variants under in vitro electroceutical treatment.Scientific reports · 2020Article
- Bioelectrical understanding and engineering of cell biology.Journal of the Royal Society, Interface · 2020Article
- Electrochemical methods to enhance osseointegrated prostheses.Biomedical engineering letters · 2020Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure loss of activity and killing when direct current was applied. Silver electrodes were overlaid with agar and lawn biofilms grown for 24 h. A 6 V battery with 1 kΩ ballast resistor was used to treat the biofilms for 1 h or 24 h. Loss of bioluminescence and a 4-log reduction in viable cells was achieved over the anode. Scanning electron microscopy showed damaged cells and disrupted biofilm architecture. The antimicrobial activity continued to spread from the anode for at least 2 days, even after turning off the current. Based on possible electrochemical ractions of silver electrodes in chlorine containing medium; pH measurements of the medium post treatment; the time delay between initiation of treatment and observed bactericidal effects; and the presence of chlorotyrosine in the cell lysates, hypochlorous acid is hypothesized to be the chemical agent responsible for the observed (destruction/killing/eradication) of these biofilm forming bacteria. Similar killing was obtained with gels containing only bovine synovial fluid or human serum. These results suggest that our in vitro model could serve as a platform for fundamental studies to explore the effects of electrochemical treatment on biofilms, complementing clinical studies with electroceutical dressings.
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