Evidence map›Paper›PMID 30765538›Full record

ArticleScience (New York, N.Y.)2019

The human gut bacterial genotoxin colibactin alkylates DNA.

Matthew R Wilson, Yindi Jiang, Peter W Villalta, Alessia Stornetta, Paul D Boudreau, Andrea Carrá, Caitlin A Brennan, Eunyoung Chun, Lizzie Ngo, Leona D Samson and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 378 papers.

0numbers the graph read from it
0cells of the map it votes in
378citing papers in PubMed
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

378 citing papers in PubMed, 614 citations in OpenAlex.

  1. Review
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  4. Article
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  6. Article
  7. Article
  8. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Harnessing the microbiome for cancer therapy.Nature reviews. Microbiology · 2026
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

318 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Matthew R Wilson *Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.ORCID 0000-0001-8047-9469
Yindi Jiang *Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.ORCID 0000-0002-5893-8419
Peter W VillaltaMasonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA.ORCID 0000-0002-0067-3083
Alessia StornettaMasonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA.ORCID 0000-0002-8287-9551
Paul D BoudreauDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.ORCID 0000-0001-5416-4404
Andrea CarráMasonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA.ORCID 0000-0003-1770-017X
Caitlin A BrennanDepartment of Immunology and Infectious Diseases and Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-6074-9502
Eunyoung ChunDepartment of Immunology and Infectious Diseases and Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-7444-7559
Lizzie NgoDepartment of Biological Engineering, MIT, Cambridge, MA 02139, USA.ORCID 0000-0001-7455-5648
Leona D SamsonDepartment of Biological Engineering, MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-7112-1454
Bevin P EngelwardDepartment of Biological Engineering, MIT, Cambridge, MA 02139, USA.ORCID 0000-0003-4322-3573
Wendy S GarrettDepartment of Immunology and Infectious Diseases and Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-5092-0150
Silvia BalboMasonic Cancer Center, University of Minnesota, 2231 Sixth Street Southeast, Minneapolis, MN 55455, USA. balskus@chemistry.harvard.edu balbo006@umn.edu.ORCID 0000-0002-7686-0504
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA. balskus@chemistry.harvard.edu balbo006@umn.edu.ORCID 0000-0001-5985-5714
Harvard University · USUniversity of Minnesota Medical Center · USIIT@MIT · USBroad Institute · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Gut microbiota and inflammatory monocytes in colorectal cancerR01CA154426 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI GARRETT, WENDY S. · 2011 to 2025
$5.2M
Understanding the Mechanism of a Gut Microbial Genotoxin Involved in Colorectal CarcinogenesisR01CA208834 · NCI · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2016 to 2025
$3.7M
Cancer Immunology Training GrantT32CA207021 · NCI · DANA-FARBER CANCER INST · PI WUCHERPFENNIG, KAI W · 2016 to 2020
$2.4M
Mass Spectrometric Analytical Collaborations with Members of the Masonic Cancer Center of the University of MinnesotaR50CA211256 · NCI · UNIVERSITY OF MINNESOTA · PI Peter William Villalta · 2016 to 2026
$2.1M
Eukaryotic DNA Alkylation RepairR01ES022872 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAMSON, LEONA D. · 2013 to 2017
$1.7M
CometChip: Development of a high throughput DNA damage assay in hepatocytesR44ES024698 · NIEHS · INTEGRATED LABORATORY SYSTEMS, LLC · PI ENGELWARD, BEVIN P., RECIO, LESLIE · 2014 to 2016
$1.6M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA154426NCI NIH HHS R01 CA208834NCI NIH HHS R50 CA211256NCI NIH HHS T32 CA207021NIEHS NIH HHS P30 ES002109NIEHS NIH HHS R01 ES022872NIEHS NIH HHS R44 ES024698
6 · The paper itself

Abstract

Certain

Indexed as

DNA DamageGastrointestinal MicrobiomeAlkylating AgentsAlkylationAnimalsCarcinogenesisColorectal NeoplasmsCyclopropanesDNA AdductsEscherichia coliGerm-Free LifeHeLa CellsHT29 CellsHumansMiceMice, Inbred C57BLAlkylating AgentscolibactincyclopropaneCyclopropanesDNA AdductsMutagensPeptidesPolyketides

Identifiers

PMID30765538
PMCPMC6407708
OpenAlexW2912413992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.