ArticleScience (New York, N.Y.)2019
Heterochromatin anomalies and double-stranded RNA accumulation underlie
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 1 pooled it
22.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 1 synthesis or guideline pooled it, 228 citations in OpenAlex.
- Elucidating the Role of Cerebellar Synaptic Dysfunction in C9orf72-ALS/FTD - a Systematic Review and Meta-Analysis.Cerebellum (London, England) · 2022Pooled it
- Two dipeptide repeat proteins are produced from mammalian telomeric RNA previously thought to be a long non-coding RNA.RNA biology · 2026Review
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- RAN Translation-Coupled Decay of theInternational journal of molecular sciences · 2026Article
- Nuclear dysfunction in aging and neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Condensate protein aggregation in ALS/FTD is regulated by GGGGCC-repeat RNA scaffolds.Nature structural & molecular biology · 2026Article
- Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD.iScience · 2026Article
- Emergence of satellite DNAs suggests centromeric repositioning as a driver of karyotypic variation of the freshwater darter characines (Apareiodon affinis).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration inInternational journal of molecular sciences · 2026Article
- Analysis of Endogenously Expressed Double-Stranded RNAs in Human Cultured Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Engineering 3D neural models of neurodegeneration: the Neural Microenvironment Design Code (NMDC), design principles, and emerging new approach methodologies.NAM journal · 2026Review
- Article
- The telomeric valine-arginine dipeptide repeat protein changes state to diffuse staining in mitosis and represses in vitro translation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Article
- Article
- Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons.bioRxiv : the preprint server for biology · 2025Article
- Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.Disease models & mechanisms · 2025Article
- Pathophysiology, Clinical Heterogeneity, and Therapeutic Advances in Amyotrophic Lateral Sclerosis: A Comprehensive Review of Molecular Mechanisms, Diagnostic Challenges, and Multidisciplinary Management Strategies.Life (Basel, Switzerland) · 2025Review
- Neuronal polyunsaturated fatty acids are protective in ALS/FTD.Nature neuroscience · 2025Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 8 institutions in 1 country.
Yong-Jie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-9900-4313
Lin GuoDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2589-9513
Patrick K GonzalesDepartment of Integrative Physiology, Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.ORCID 0000-0002-2082-3835
Tania F GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-7335-2627
Yanwei WuDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Karen Jansen-WestDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Aliesha D O'RawDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-6618-3036
Sarah R PicklesDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0001-7956-4586
Mercedes PrudencioDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-4894-4858
Yari CarlomagnoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0001-5530-7737
Mariam A GachechiladzeNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Connor LudwigInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, and Chan Zuckerberg Biohub, San Francisco, CA, USA.
Ruilin TianInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, and Chan Zuckerberg Biohub, San Francisco, CA, USA.
Jeannie ChewDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-7176-5655
Michael DeTureDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-4363-1262
Wen-Lang LinDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Jimei TongDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Lillian M DaughrityDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0003-4644-7265
Mei YueDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Yuping SongDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Jonathan W AndersenDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Monica Castanedes-CaseyDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-8441-7801
Aishe KurtiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Abhishek DattaProtein Chemistry, Biogen Idec, Cambridge, MA, USA.
Giovanna AntognettiProtein Chemistry, Biogen Idec, Cambridge, MA, USA.
Alexander McCampbellNeurology Research, Biogen Idec, Cambridge, MA, USA.ORCID 0000-0002-1984-6052
Rosa RademakersDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-4049-0863
Björn OskarssonDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0002-1725-9866
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID 0000-0001-7189-7917
Martin KampmannInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, and Chan Zuckerberg Biohub, San Francisco, CA, USA.ORCID 0000-0002-3819-7019
Michael E WardNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5296-8051
John D FryerDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Christopher D LinkDepartment of Integrative Physiology, Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
James ShorterDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5269-8533
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. petrucelli.leonard@mayo.edu.ORCID 0000-0003-2959-129X
Mayo Clinic in Florida · USJacksonville College · USBiogen (United States) · USChan Zuckerberg Initiative (United States) · USNational Institutes of Health · USUniversity of Colorado Boulder · USUniversity of Pennsylvania · USWinnMed · US
Funding
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6MProject 3: Autophagy dysfunction and neuronal activity in FTDU54NS100717 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KOSIK, KENNETH STEPHEN · 2016 to 2020
$10.8MExpanding insights into FTD disease mechanismsR35NS097273 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2017 to 2024
$10.6MValidation of r(G4C2)exp-binding small molecules in vivo and c9FTD/ALS biomarker developmentP01NS099114 · NINDS · UNIVERSITY OF FLORIDA · PI DISNEY, MATTHEW D · 2017 to 2021
$6.5MTDP-43, RNA Metabolism, and ALS/FTD PathologyR01NS063964 · NINDS · UNIVERSITY OF COLORADO · PI LINK, CHRISTOPHER D. · 2009 to 2019
$3.5MSystematic elucidation of endosomal trafficking as a therapeutic opportunity in AD using CRISPR-based functional genomicsR01AG062359 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN · 2018 to 2022
$3.2MRewiring of the human protein homeostasis network in normal and disease contextsDP2GM119139 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN · 2015 to 2015
$2.3MSilencing C9or72 with rAAV Mediated RNAiR01NS088689 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BROWN, ROBERT H., MUELLER, CHRISTIAN · 2014 to 2017
$1.6MUncovering mechanisms of selective vulnerability by CRISPR-based genetic screensR56AG057528 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRINBERG, LEA TENENHOLZ, KAMPMANN, MARTIN · 2018 to 2018
$769kNIA NIH HHS R01 AG062359NIA NIH HHS R56 AG057528NIGMS NIH HHS DP2 GM119139NINDS NIH HHS P01 NS084974NINDS NIH HHS P01 NS099114NINDS NIH HHS R01 NS063964NINDS NIH HHS R01 NS088689NINDS NIH HHS R35 NS097273NINDS NIH HHS U54 NS100717
Abstract
How hexanucleotide GGGGCC (G
Indexed as
Amyotrophic Lateral SclerosisAnimalsBrainC9orf72 ProteinChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDipeptidesDisease Models, AnimalGreen Fluorescent ProteinsHEK293 CellsHeterochromatinHumansMiceMice, Inbred C57BLNuclear LaminaRepetitive Sequences, Nucleic AcidC9orf72 ProteinC9orf72 protein, humanCBX5 protein, humanChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDipeptidesGreen Fluorescent ProteinsHeterochromatinprolylarginineRNA, Double-Stranded
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.