ArticleProceedings of the National Academy of Sciences of the United States of America2019
Evolution of resilience in protein interactomes across the tree of life.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Article
- Network resilience of the human interactome to pan-cancer mutations reveals conserved pathway vulnerabilities.iScience · 2026Article
- Combinatorial prediction of therapeutic perturbations using causally inspired neural networks.Nature biomedical engineering · 2026Article
- A Novel Integrative Framework for Depression: Combining Network Pharmacology, Artificial Intelligence, and Multi-Omics with a Focus on the Microbiota-Gut-Brain Axis.Current issues in molecular biology · 2025Review
- Few shot learning for phenotype-driven diagnosis of patients with rare genetic diseases.NPJ digital medicine · 2025Article
- Self-Supervised Based Multi-View Graph Presentation Learning for Drug-Drug Interaction Prediction.Transactions on artificial intelligence · 2025Article
- Sustainable heavy metal immobilization in contaminated soils using plant-derived urease-driven biomineralization.PloS one · 2025Article
- Resilience and evolutionary insights in PPI networks: comparative analysis of node resilience and centrality measures.Frontiers in genetics · 2025Article
- Exploring the role of the Rab network in epithelial-to-mesenchymal transition.Bioinformatics advances · 2025Article
- A foundation model for clinician-centered drug repurposing.Nature medicine · 2024Article
- Global meta-analysis reveals the drivers of gut microbiome variation across vertebrates.iMetaOmics · 2024Article
- Using residue interaction networks to understand protein function and evolution and to engineer new proteins.Current opinion in structural biology · 2024Review
- A statistical mechanics investigation of unfolded protein response across organisms.Scientific reports · 2024Article
- Article
- Review
- Key interaction networks: Identifying evolutionarily conserved non-covalent interaction networks across protein families.Protein science : a publication of the Protein Society · 2024Article
- Current and future directions in network biology.Bioinformatics advances · 2024Article
- Exploring the landscape of dismantling strategies based on the community structure of networks.Scientific reports · 2023Article
- Understanding and applying biological resilience, from genes to ecosystems.npj biodiversity · 2023Review
- Landscape-level variability and insect herbivore outbreak captured within modern forests provides a framework for interpreting the fossil record.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Phenotype robustness to environmental fluctuations is a common biological phenomenon. Although most phenotypes involve multiple proteins that interact with each other, the basic principles of how such interactome networks respond to environmental unpredictability and change during evolution are largely unknown. Here we study interactomes of 1,840 species across the tree of life involving a total of 8,762,166 protein-protein interactions. Our study focuses on the resilience of interactomes to network failures and finds that interactomes become more resilient during evolution, meaning that interactomes become more robust to network failures over time. In bacteria, we find that a more resilient interactome is in turn associated with the greater ability of the organism to survive in a more complex, variable, and competitive environment. We find that at the protein family level proteins exhibit a coordinated rewiring of interactions over time and that a resilient interactome arises through gradual change of the network topology. Our findings have implications for understanding molecular network structure in the context of both evolution and environment.
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Registered trials
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