ArticleJournal of cell science2019
VEGFR2 survival and mitotic signaling depends on joint activation of associated C3ar1/C5ar1 and IL-6R-gp130.
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Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Effects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dual role of complement in neuronal repair.Frontiers in immunology · 2025Review
- Hypoxia-induced complement component 3 promotes aggressive tumor growth in the glioblastoma microenvironment.JCI insight · 2024Article
- Critical Role of CD55 in Controlling Wound Healing.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Disabled C3ar1/C5ar1 Signaling in Foxp3+ T Regulatory Cells Leads to TSDR Demethylation and Long-Term Stability.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood-Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation.ACS applied nano materials · 2023Article
- Endothelial-Specific Targeting of RhoA Signaling via CD31 Antibody-Conjugated Nanoparticles.The Journal of pharmacology and experimental therapeutics · 2023Article
- Identification of immune associated potential molecular targets in proliferative diabetic retinopathy.BMC ophthalmology · 2023Article
- Unveiling COVID-19 Secrets: Harnessing Cytokines as Powerful Biomarkers for Diagnosis and Predicting Severity.Journal of inflammation research · 2023Article
- KLF4 and CD55 expression and function depend on each other.Frontiers in immunology · 2023Article
- Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling.The American journal of pathology · 2022Article
- Comprehensive Analysis of Regulatory Network for LINC00472 in Clear Cell Renal Cell Carcinoma.Journal of healthcare engineering · 2021Article
- Unraveling the molecular mechanisms between inflammation and tumor angiogenesis.American journal of cancer research · 2021Review
- In response to complement anaphylatoxin peptides C3a and C5a, human vascular endothelial cells migrate and mediate the activation of B-cells and polarization of T-cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- RTK signaling requires C3ar1/C5ar1 and IL-6R joint signaling to repress dominant PTEN, SOCS1/3 and PHLPP restraint.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Integrated bioinformatics analysis reveals novel hub genes closely associated with pathological mechanisms of immunoglobulin A nephropathy.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Ming-Shih HwangDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-9044-3099
Michael G StrainicDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0003-2438-8540
Elliot PohlmannDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Haesuk KimDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Elzbieta PluskotaDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland OH 44195, USA.
Diana L Ramirez-BergeronCase Cardiovascular Research Institute and University Hospitals, Case Western Reserve University School of Medicine and University Hospitals, Cleveland, Ohio 44106, USA.ORCID 0000-0002-0989-3429
Edward F PlowDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland OH 44195, USA.ORCID 0000-0003-1531-9746
M Edward MedofDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA mxm16@case.edu.ORCID 0000-0001-5239-2518
Case Western Reserve University · USCleveland Clinic Lerner College of Medicine · USUniversity School · US
Funding
Structure Basis for Talin-mediated Integrin ActivationP01HL073311 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2004 to 2019
$27.4MTISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7MActivation of the beta-3 integrins: Role of the KindlinsR01HL096062 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2009 to 2022
$5.6MThe Role of ARNT in Endothelial CellsR01HL096597 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI RAMIREZ-BERGERON, DIANA L · 2011 to 2015
$2.0MOptimizing mesenchymal stem cell and Treg immunosuppression for controlling SLER01AR067182 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI MEDOF, MELVIN EDWARD · 2015 to 2019
$1.7MLocal Complement Synthesis and Signaling by Endothelial and Inflammatory CellsR01HL109561 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MEDOF, MELVIN EDWARD · 2012 to 2015
$1.5MNEI NIH HHS P30 EY011373NHLBI NIH HHS P01 HL073311NHLBI NIH HHS R01 HL096062NHLBI NIH HHS R01 HL096597NHLBI NIH HHS R01 HL109561NIAMS NIH HHS R01 AR067182
Abstract
Purified vascular endothelial cell (EC) growth factor receptor-2 (VEGFR2) auto-phosphorylates upon VEGF-A occupation
Indexed as
AnimalsCell ProliferationCytokine Receptor gp130Endothelial CellsInterleukin-6MiceNeovascularization, PhysiologicReceptor, Anaphylatoxin C5aReceptors, ComplementSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth FactorsC5ar1 protein, mousecomplement C3a receptorCytokine Receptor gp130Interleukin-6Receptor, Anaphylatoxin C5aReceptors, ComplementVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth FactorsC5ar1Cellular growthIL-6RRTK signalingVEGF-AVEGFR2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.