ArticleThe Journal of cell biology2019
CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.
Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Chromosome condensation mechanically primes the nucleus for mitosis.The EMBO journal · 2026Article
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- ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non-Small Cell Lung Cancer.Exploration (Beijing, China) · 2025Article
- The ABCs of the H2Bs: The histone H2B sequences, variants, and modifications.Trends in genetics : TIG · 2025Review
- The Aurora B-controlled PP1/RepoMan complex determines the spatial and temporal distribution of mitotic H2B S6 phosphorylation.Open biology · 2024Article
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- Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma.Cancers · 2022Article
- Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1.Frontiers in oncology · 2022Review
- AFrontiers in genetics · 2021Article
- Overexpression of Taspase 1 Predicts Poor Prognosis in Patients with Hepatocellular Carcinoma.Cancer management and research · 2021Article
- Functioning mechanisms of Shugoshin-1 in centromeric cohesion during mitosis.Essays in biochemistry · 2020Review
- Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells.Molecular cell · 2020Article
- Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites.Nature communications · 2020Article
- Priming chromatin for segregation: functional roles of mitotic histone modifications.Cell cycle (Georgetown, Tex.) · 2020Review
- SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism.Scientific reports · 2020Article
- SET binding to Sgo1 inhibits Sgo1-cohesin interactions and promotes chromosome segregation.The Journal of cell biology · 2019Article
- Cell cycle regulation and hematologic malignancies.Blood science (Baltimore, Md.) · 2019Review
- Quantitative Phosphoproteomic and Physiological Analyses Provide Insights into the Formation of the Variegated Leaf inInternational journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
Abstract
Faithful mitotic chromosome segregation is required for the maintenance of genomic stability. We discovered the phosphorylation of histone H2B at serine 6 (H2B S6ph) as a new chromatin modification site and found that this modification occurs during the early mitotic phases at inner centromeres and pericentromeric heterochromatin. This modification is directly mediated by cyclin B1-associated CDK1, and indirectly by Aurora B, and is antagonized by PP1-mediated dephosphorylation. H2B S6ph impairs chromatin binding of the histone chaperone SET (I2PP2A), which is important for mitotic fidelity. Injection of phosphorylation-specific H2B S6 antibodies in mitotic cells caused anaphase defects with impaired chromosome segregation and incomplete cytokinesis. As H2B S6ph is important for faithful chromosome separation, this modification may contribute to the prevention chromosomal instability and aneuploidy which frequently occur in cancer cells.
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Registered trials
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