ArticleJournal of neurology, neurosurgery, and psychiatry2019
Shorter pulse width reduces gait disturbances following deep brain stimulation for essential tremor.
Article in Journal of neurology, neurosurgery, and psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Deep Brain Stimulation for Arm Tremor: A Randomized Trial Comparing Two Targets.Annals of neurology · 2022Trial
- A Randomized, Double-Blinded Crossover Trial of Short Versus Conventional Pulse Width Subthalamic Deep Brain Stimulation in Parkinson's Disease.Journal of Parkinson's disease · 2022Trial
- Tremor and disability outcomes following deep brain stimulation for multiple sclerosis-associated tremor.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Bradykinesia induced by pallidal neurostimulation in dystonia: clinical risk factors and anatomical mapping.NPJ Parkinson's disease · 2025Article
- Rebound Tremor Frequency as a Potential Diagnostic Marker for Delayed Therapy Escape after Thalamic Deep Brain Stimulation for Essential Tremor-Insights from a Cross-Sectional Study.Brain sciences · 2024Article
- Management of essential tremor deep brain stimulation-induced side effects.Frontiers in human neuroscience · 2024Review
- Active recharge biphasic stimulation for the intraoperative monopolar review in deep brain stimulation.Frontiers in human neuroscience · 2024Article
- Advances in DBS Technology and Novel Applications: Focus on Movement Disorders.Current neurology and neuroscience reports · 2022Review
- Short pulse and directional thalamic deep brain stimulation have differential effects in parkinsonian and essential tremor.Scientific reports · 2022Article
- Milestones in Tremor Research: 10 Years Later.Movement disorders clinical practice · 2022Review
- Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.Frontiers in neurology · 2022Review
- Deep Brain Stimulation for Tremor: Update on Long-Term Outcomes, Target Considerations and Future Directions.Journal of clinical medicine · 2021Review
- Habituation After Deep Brain Stimulation in Tremor Syndromes: Prevalence, Risk Factors and Long-Term Outcomes.Frontiers in neurology · 2021Review
- The Relationship Between Electrical Energy Delivered by Deep Brain Stimulation and Levodopa-Induced Dyskinesias in Parkinson's Disease: A Retrospective Preliminary Analysis.Frontiers in neurology · 2021Article
- Stimulation-Induced Side Effects of Deep Brain Stimulation in the Ventralis Intermedius and Posterior Subthalamic Area for Essential Tremor.Frontiers in neurology · 2021Article
- Neural selectivity, efficiency, and dose equivalence in deep brain stimulation through pulse width tuning and segmented electrodes.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGait disturbances are frequent side effects occurring during chronic thalamic deep brain stimulation (DBS) in patients with essential tremor (ET). Adapting stimulation settings to shorter pulse widths has been shown to reduce side effects of subthalamic DBS. Here, we assess how a reduction of pulse width changes gait performance of affected patients.
methodsSensor-based gait assessment was performed to record spatiotemporal gait parameters in 10 healthy subjects (HS) and 7 patients with ET with gait disturbances following thalamic DBS. Patients were tested during standard DBS, after 72 hours of stimulation withdrawal and at least 30 days after adjusting DBS settings to a shorter pulse width of 40 µs (DBS40PW).
resultsPatients with ET on standard DBS showed significantly higher variability of several spatiotemporal gait parameters compared with HS. Variability of stride length and range of motion of the shanks significantly decreased OFF DBS as compared with standard DBS. This improvement was maintained over 30 days with DBS40PW while providing effective tremor suppression in six out of seven patients.
conclusionShorter pulse widths may reduce gait disturbances in patients with ET that are induced by DBS while preserving a level of tremor suppression equal to standard stimulation settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.