Evidence map›Paper›PMID 30765166›Full record

ArticleNeuron2019

Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation.

Davide Folloni, Lennart Verhagen, Rogier B Mars, Elsa Fouragnan, Charlotte Constans, Jean-François Aubry, Matthew F S Rushworth, Jérôme Sallet

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 204 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06939348 narecruitingnot on this mapstarted 2025, after this paper: background citation

Safety and Efficacy of Thalamic Focused Ultrasound Stimulation (tFUS) for Promoting Recovery After Severe Traumatic Brain Injury

TypeinterventionalSponsorUniversity of California, Los AngelesRan2025 to 2028Enrolled60ConditionsConsciousness Disorders, Disorders of Consciousness Due to Severe Brain InjuryArmsThe Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
NCT07518927 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Mapping Low-Intensity Focused Ultrasound (LIFU)-Evoked Brain Network Responses Using Intracranial Electrophysiological Recordings

TypeinterventionalSponsorUniversity of PennsylvaniaRan2026 to 2031Enrolled30ConditionsLow Intensity Focussed Ultrasound, Electrodes, ImplantedArmsLow Intensity Focused Ultrasound
3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  6. Transcranial Ultrasound Stimulation of Internal Globus Pallidus Region and Motor Cortex in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
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  18. Shining light in deep tissue.Nature materials · 2026
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144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Davide FolloniWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address: davide.folloni@psy.ox.ac.uk.
Lennart VerhagenWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address: lennart.verhagen@psy.ox.ac.uk.
Rogier B MarsWellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 HR Nijmegen, the Netherlands.
Elsa FouragnanWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; School of Psychology, University of Plymouth, Plymouth PL4 8AA, UK.
Charlotte ConstansPhysics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Univ Paris Diderot, Sorbonne Paris Cité, Paris 75012, France.
Jean-François AubryPhysics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Paris 75012, France.
Matthew F S RushworthWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Jérôme SalletWellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address: jerome.sallet@psy.ox.ac.uk.

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council G0600994Medical Research Council G0902373Medical Research Council MR/P024955/1Wellcome Trust
6 · The paper itself

Abstract

The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas of the primate brain. Here, we demonstrate that a focused transcranial ultrasound stimulation (TUS) protocol impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1), and a deep cortical region, the anterior cingulate cortex (ACC, experiment 2), in macaques. TUS neuromodulatory effects were measured by examining relationships between activity in each area and the rest of the brain using functional magnetic resonance imaging (fMRI). In control conditions without sonication, activity in a given area is related to activity in interconnected regions, but such relationships are reduced after sonication, specifically for the targeted areas. Dissociable and focal effects on neural activity could not be explained by auditory confounds.

Indexed as

Ultrasonic WavesAmygdalaAnimalsBrainBrain MappingFunctional NeuroimagingGyrus CinguliMacacaMagnetic Resonance ImagingNeural Pathwaysamygdalacingulate cortexfunctional connectivitylimbicmacaque monkeyneuromodulationresting-state connectivitytranscranial stimulationultrasound

Identifiers

PMID30765166
PMCPMC6520498

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.