Evidence map›Paper›PMID 30764786›Full record

Observational studyBMC public health2019

Effect of ART scale-up and female migration intensity on risk of HIV acquisition: results from a population-based cohort in KwaZulu-Natal, South Africa.

Armstrong Dzomba, Andrew Tomita, Alain Vandormael, Kaymarlin Govender, Frank Tanser

Abstract readObservational Study
In one paragraph

Observational study in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  17. "Barriers to Accessing Targeted Interventions among Key Populations in Jharkhand, India: A Mixed-Methods Study in Two Mining Towns".Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Armstrong DzombaAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa. dzombaarmstrong625@gmail.com.
Andrew TomitaAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Alain VandormaelAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.
Kaymarlin GovenderHealth Economics and HIV and AIDS Research Division (HEARD), University of KwaZulu-Natal, Durban, South Africa.
Frank TanserAfrica Health Research Institute (AHRI), KwaZulu-Natal, South Africa.

Funding

Causal Pathways to population health impact of HIV antiretroviral treatmentR01HD084233 · NICHD · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2015 to 2021
$2.3M
Can HIV Hot-Spots be eradicated? An intervention to decrease HIV transmission to young women in rural KwaZulu-Natal South AfricaR01AI124389 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2016 to 2020
$2.1M
Academy of Medical Sciences NA150161National Institutes of Health R01AI124389National Institutes of Health R01HD084233NIAID NIH HHS R01 AI124389NICHD NIH HHS R01 HD084233South African Medical Research Council MRC-RFA-UFSP-01-2013/UKZN HIVEPIWellcome Trust
6 · The paper itself

Abstract

backgroundDespite increased antiretroviral therapy (ART) coverage, the incidence of HIV infection among women in rural South Africa remains high. While many socio-demographic and behavioral factors have been identified, the effect of female migration intensity on the risk of HIV acquisition before and after ART scale-up has not been evaluated in the country.

methodsWe followed 13,315 female participants aged 15-49 who were HIV-uninfected at baseline and recorded their migration events between 2004 and 2015. Using a Cox proportional hazard model, we estimated the time to HIV acquisition among the women, adjusting for annual migration intensity (high: ≥2 events/year, moderate = 1 event/year, and low = 0 event/year) before and after ART scale-up in 2010.

results1998 (15%) new HIV-infection events were recorded during the observation period. Overall, high migration intensity was associated with an increased HIV acquisition risk among women when compared with low migration intensity (HR = 2.88, 95% CI: 1.56-5.53). Among those with high migration intensity, the risk of HIV acquisition was significantly lower in the post-ART period compared to the pre-ART period, after controlling for key socio-demographic and behavioural covariates (aHR = 0.18, 95% CI 0.04-0.83).

conclusionsWomen who migrated frequently after ART scale-up had a significantly reduced HIV acquisition risk compared to those before its implementation. While this reduction is encouraging, women who migrate frequently remain at high risk of HIV acquisition. In the era of ART, there remains a critical need for public health interventions to reduce the risk of HIV acquisition in this highly vulnerable population.

Indexed as

AdolescentAdultAnti-Retroviral AgentsCohort StudiesFemaleHIV InfectionsHumansIncidenceMiddle AgedRural PopulationSouth AfricaTransients and MigrantsYoung AdultAnti-Retroviral AgentsART scale-upFemale migrantsMigration intensityNew HIV infectionsRisk of HIV acquisitionSouth AfricaUniversal test and treat

Identifiers

PMID30764786
PMCPMC6376673

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.