Evidence map›Paper›PMID 30764779›Full record

ArticleBMC infectious diseases2019

Comparison of influenza disease burden in older populations of Hong Kong and Brisbane: the impact of influenza and pneumococcal vaccination.

Lin Yang, King Pan Chan, Chit Ming Wong, Susan Shui Seng Chiu, Ricardo J Soares Magalhaes, Thuan Quoc Thach, Joseph Syrial Malik Peiris, Archie C A Clements, Wenbiao Hu

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Lin YangGH515, School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Hong Kong, Special Administrative Region of China. l.yang@polyu.edu.hk.ORCID http://orcid.org/0000-0002-5964-3233
King Pan ChanSchool of Public Health, The University of Hong Kong, Hong Kong, Hong Kong, Special Administrative Region of China.
Chit Ming WongSchool of Public Health, The University of Hong Kong, Hong Kong, Hong Kong, Special Administrative Region of China.
Susan Shui Seng ChiuDepartment of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, Hong Kong, Special Administrative Region of China.
Ricardo J Soares MagalhaesSchool of Veterinary Science, University of Queensland, Brisbane, Australia.
Thuan Quoc ThachSchool of Public Health, The University of Hong Kong, Hong Kong, Hong Kong, Special Administrative Region of China.
Joseph Syrial Malik PeirisSchool of Public Health, The University of Hong Kong, Hong Kong, Hong Kong, Special Administrative Region of China.
Archie C A ClementsResearch School of Population Health, The Australian National University, Canberra, Australia.
Wenbiao HuSchool of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.
University of Hong Kong · HKAustralian National University · AUHong Kong Polytechnic University · HKQueensland University of Technology · AUThe University of Queensland · AU

Funding

Health and Medical Research Fund 13121282Hong Kong Polytechnic University G-UADY
6 · The paper itself

Abstract

backgroundInfluenza and pneumococcal vaccine uptake in the older population aged 65 years or over of Hong Kong dramatically increased since the 2003 SARS outbreak. This study is aimed to evaluate the impact of increased coverage of influenza and pneumococcal vaccines by comparing the change of disease burden in the older population of Hong Kong, with the burden in the older population of Brisbane with relatively high vaccine coverage in the past fifteen years.

methodsTime series segmented regression models were applied to weekly numbers of cause-specific mortality or hospitalization of Hong Kong and Brisbane. Annual excess rates of mortality or hospitalization associated with influenza in the older population were estimated for the pre-SARS (reference period), post-SARS and post-pandemic period, respectively. The rate ratios (RRs) between these periods were also calculated to assess the relative change of disease burden.

resultsCompared to the pre-SARS period, excess rates of mortality associated with influenza during the post-SARS period in Hong Kong decreased for cardiorespiratory diseases (RR = 0.90, 95% CI 0.80, 1.01), stroke (RR = 0.74, 95% CI 0.50, 1.09), and ischemic heart diseases (RR = 0.45, 95% CI 0.34, 0.58). The corresponding RRs in Brisbane were 0.79 (95% CI 0.54, 1.15), 0.33 (0.13, 0.80), and 1.09 (0.62, 1.90), respectively. Only the mortality of ischemic heart diseases showed a greater reduction in Hong Kong than in Brisbane. During the post-pandemic period, excess rates of all-cause mortality increased in Hong Kong, but to a lesser extent than in Brisbane (RR = 1.41 vs 2.39).

conclusionA relative decrease (or less of an increase) of influenza disease burden was observed in the older population of Hong Kong after increased coverage of influenza and pneumococcal vaccines in this population, as compared to those of Brisbane where vaccination rates remained stable. The lack of significant findings in some disease categories highlights the challenges of evaluating the benefits of vaccination at the population level.

Indexed as

VaccinationAgedAged, 80 and overAge FactorsAustraliaFemaleHong KongHospitalizationHumansInfluenza, HumanInfluenza VaccinesMalePandemicsPneumococcal VaccinesInfluenza VaccinesPneumococcal VaccinesDisease burdenElderlyInfluenzaMorbidityMortalityVaccine

Identifiers

PMID30764779
PMCPMC6376732
OpenAlexW2932492670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.