Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Intermittent hypoxia training improves cerebral blood flow without cognitive impairment.Annals of clinical and translational neurology · 2025Trial
- One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Age differences in spontaneous cerebrovascular reactivity at rest.GeroScience · 2026Article
- Interaction between systemic arterial reservoir behavior and cerebrovascular vasoreactivity during acute controlled hypocapnia.Scientific reports · 2026Article
- A cascade model of dynamic cerebral autoregulation.The Journal of physiology · 2026Article
- Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study.The Journal of physiology · 2026Article
- Article
- The pathobiology of neurovascular aging.Neuron · 2025Review
- Revealing the Spatial Pattern of Brain Hemodynamic Sensitivity to Healthy Aging through Sparse Dynamic Causal Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Variable cerebral blood flow responsiveness to acute hypoxic hypoxia.Frontiers in physiology · 2025Article
- Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults.Aging and disease · 2024Review
- Cerebrovascular COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cerebral blood flow and cerebrovascular resistance across the adult lifespan: A multimodality approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- A framework of transient hypercapnia to achieve an increased cerebral blood flow induced by nasal breathing during aerobic exercise.Cerebral circulation - cognition and behavior · 2023Review
- Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis.Frontiers in endocrinology · 2023Review
- The relationships between age, sex, and cerebrovascular reactivity to hypercapnia using traditional and kinetic-based analyses in healthy adults.American journal of physiology. Heart and circulatory physiology · 2022Article
- Cerebrovascular reactivity deficits in cognitively unimpaired older adults: vasodilatory versus vasoconstrictive responses.Neurobiology of aging · 2022Article
- Association between the reactivity of local cerebral oxygen saturation after hypo-to-hypercapnic tests and delirium after abdominal surgery in older adults: A prospective study.Frontiers in psychiatry · 2022Article
- Midlife aerobic exercise and dynamic cerebral autoregulation: associations with baroreflex sensitivity and central arterial stiffness.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Exercise, Arterial Stiffness, and Cerebral Vascular Function: Potential Impact on Brain Health.Journal of the International Neuropsychological Society : JINS · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Age is the strongest risk factor for cerebrovascular disease; however, age-related changes in cerebrovascular function are still not well understood. The objective of this study was to measure cerebral vasomotor reactivity (CVMR) during hypo- and hypercapnia across the adult lifespan. One hundred fifty-three healthy participants (21-80 years) underwent measurements of cerebral blood flow velocity (CBFV) via transcranial Doppler, mean arterial pressure (MAP) via plethysmograph, and end-tidal CO
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.