Evidence map›Paper›PMID 30764497›Full record

ArticleNutrients2019

Autism Spectrum Disorder (ASD) with and without Mental Regression is Associated with Changes in the Fecal Microbiota.

Julio Plaza-Díaz, Antonio Gómez-Fernández, Natalia Chueca, María José de la Torre-Aguilar, Ángel Gil, Juan Luis Perez-Navero, Katherine Flores-Rojas, Pilar Martín-Borreguero, Patricio Solis-Urra, Francisco Javier Ruiz-Ojeda and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Microbiota in Autism Spectrum Disorder: A Systematic Review.International journal of molecular sciences · 2023
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  6. A Meta-analysis of Gut Microbiota in Children with Autism.Journal of autism and developmental disorders · 2022
    Pooled it
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  11. Observational
  12. The Microbiota in the Diagnosis and Treatment of Autism Spectrum Disorder.International journal of molecular sciences · 2026
    Review
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  17. Supplementation with abioRxiv : the preprint server for biology · 2025
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julio Plaza-DíazDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain;. jrplaza@ugr.es.ORCID 0000-0002-5171-9408
Antonio Gómez-FernándezPediatric Research and Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute forBiomedical Research of Córdoba (IMIBIC), University of Córdoba, 14010 Córdoba, Spain. antoniogofedez@hotmail.com.
Natalia ChuecaInstituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada,18014 Granada, Spain. naisses@yahoo.es.
María José de la Torre-AguilarPediatric Research and Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute forBiomedical Research of Córdoba (IMIBIC), University of Córdoba, 14010 Córdoba, Spain. delatorremj4@gmail.com.
Ángel GilDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain;. agil@ugr.es.ORCID 0000-0001-7663-0939
Juan Luis Perez-NaveroPediatric Research and Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute forBiomedical Research of Córdoba (IMIBIC), University of Córdoba, 14010 Córdoba, Spain. jrplaza@correo.ugr.es.
Katherine Flores-RojasPediatric Research and Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute forBiomedical Research of Córdoba (IMIBIC), University of Córdoba, 14010 Córdoba, Spain. katherine1.flores@gmail.com.
Pilar Martín-BorregueroDepartment of Child and Adolescent Clinical Psychiatry and Psychology, Reina Sofia University Hospital,Maimónides Institute for Biomedical Research of Córdoba (IMIBIC), 14010 Cordoba, Spain. pmartin.psicologa@gmail.com.
Patricio Solis-UrraPROFITH "PROmoting FITness and Health through physical activity" research group, Department ofPhysical Education and Sport, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain. patricio.solis.u@gmail.com.ORCID 0000-0002-2493-9528
Francisco Javier Ruiz-OjedaRG Adipocytes and metabolism, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Center Munich, 85748 Garching, Munich, Germany. francisco.ruiz@helmholtz-muenchen.de.
Federico GarciaInstituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada,18014 Granada, Spain. fegarcia@ugr.es.ORCID 0000-0001-7611-781X
Mercedes Gil-CamposPediatric Research and Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute forBiomedical Research of Córdoba (IMIBIC), University of Córdoba, 14010 Córdoba, Spain. mercedes_gil_campos@yahoo.es.

Funding

FUNDACIÓ AGRUPACIÓ Àmbit de la Infància 404 Research Grant INVEST from the Spanish Society of Pediatrics and Red de Salud Materno Infantil (RED SAMID)
6 · The paper itself

Abstract

New microbiome sequencing technologies provide novel information about the potential interactions among intestinal microorganisms and the host in some neuropathologies as autism spectrum disorders (ASD). The microbiota⁻gut⁻brain axis is an emerging aspect in the generation of autistic behaviors; evidence from animal models suggests that intestinal microbial shifts may produce changes fitting the clinical picture of autism. The aim of the present study was to evaluate the fecal metagenomic profiles in children with ASD and compare them with healthy participants. This comparison allows us to ascertain how mental regression (an important variable in ASD) could influence the intestinal microbiota profile. For this reason, a subclassification in children with ASD by mental regression (AMR) and no mental regression (ANMR) phenotype was performed. The present report was a descriptive observational study. Forty-eight children aged 2⁻6 years with ASD were included: 30 with ANMR and 18 with AMR. In addition, a control group of 57 normally developing children was selected and matched to the ASD group by sex and age. Fecal samples were analyzed with a metagenomic approach using a next-generation sequencing platform. Several differences between children with ASD, compared with the healthy group, were detected. Namely,

Indexed as

Gastrointestinal MicrobiomeAutism Spectrum DisorderBacteriaChild, PreschoolDietDNA, BacterialFecesFemaleHigh-Throughput Nucleotide SequencingHumansMaleMetagenomicsDNA, Bacterialautism spectrum disorderchildrenintestinal microbiotanutrients

Identifiers

PMID30764497
PMCPMC6412819

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.