Evidence map›Paper›PMID 30764482›Full record

ReviewInternational journal of molecular sciences2019

Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity.

Andrea Padoan, Mario Plebani, Daniela Basso

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed, 5 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

234 citing papers in PubMed, 5 syntheses or guidelines pooled it, 349 citations in OpenAlex.

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  18. Modulating tumor mechanics and vascular barriers to enhance chemotherapy efficacy in pancreatic tumors and melanoma.Journal of controlled release : official journal of the Controlled Release Society · 2026
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174 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrea PadoanDepartment of Medicine ⁻ DIMED, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. andrea.padoan@unipd.it.
Mario PlebaniDepartment of Medicine ⁻ DIMED, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. mario.plebani@unipd.it.
Daniela BassoDepartment of Medicine ⁻ DIMED, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. daniela.basso@unipd.it.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic and local chronic inflammation might enhance the risk of pancreatic ductal adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor microenvironment concurs in enhancing tumor growth and metastasis. Inflammation is closely correlated with immunity, the same immune cell populations contributing to both inflammation and immune response. In the PDAC microenvironment, the inflammatory cell infiltrate is unbalanced towards an immunosuppressive phenotype, with a prevalence of myeloid derived suppressor cells (MDSC), M2 polarized macrophages, and T

Indexed as

ImmunityAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesHumansInflammationMacrophagesPancreasPancreatic NeoplasmsTumor MicroenvironmentCytokinesanti-TNFαcytokinesinflammationmiRNAmyeloid derived suppressor cellspancreatic cancerS100A8S100A9TNFαTreg lymphocytestumor associated macrophages

Identifiers

PMID30764482
PMCPMC6387440
OpenAlexW2913836031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.