ArticleSleep2019
Circadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepiness.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 100 citations in OpenAlex.
- Multimodal investigation of the association between shift work and the brain in a population-based sample of older adults.Scientific reports · 2022Trial
- Diurnal dynamics of multilayer brain networks predict cognitive trajectories in aging.GeroScience · 2026Article
- Oscillatory network efficiency predicts mood and fatigue during sleep deprivation.Communications biology · 2026Article
- Inflammation-associated brain functional network topological disruption in female nurses with SWSD: associations with symptoms and transcriptomics.Frontiers in immunology · 2026Article
- Colored Light Exposure Ensues Chronotype-Based Responses: Evidence From QEEG Analysis.Physiological research · 2025Article
- Altered Muscle-Brain Connectivity During Left and Right Biceps Brachii Isometric Contraction Following Sleep Deprivation: Insights from PLV and PDC.Sensors (Basel, Switzerland) · 2025Article
- Chronotype, cognitive outcomes, and neural dynamics: recent evidence and potential mechanisms with implications for perioperative period.Frontiers in neuroscience · 2025Review
- Morningness and Conscientiousness: A Meta-analysis, Online Survey and Resting fMRI Study.Journal of circadian rhythms · 2025Article
- Associating EEG functional networks and the effect of sleep deprivation as measured using psychomotor vigilance tests.Scientific reports · 2024Article
- Diurnal Fluctuations in Steroid Hormones Tied to Variation in Intrinsic Functional Connectivity in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Different emotion regulation strategies mediate the relations of corresponding connections within the default-mode network to sleep quality.Brain imaging and behavior · 2024Article
- The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep.PloS one · 2024Article
- Association of chronotype with language and episodic memory processing in children: implications for brain structure.Frontiers in integrative neuroscience · 2024Article
- Diurnal fluctuations in steroid hormones tied to variation in intrinsic functional connectivity in a densely sampled male.bioRxiv : the preprint server for biology · 2023Article
- Relation of resting brain signal variability to cognitive and socioemotional measures in an adult lifespan sample.Social cognitive and affective neuroscience · 2023Article
- Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Clinical characteristics and risk factors of acute acquired concomitant esotropia in last 5 years: a retrospective case-control study.Eye (London, England) · 2023Article
- Classification of human chronotype based on fMRI network-based statistics.Frontiers in neuroscience · 2023Article
- Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.Progress in neurobiology · 2022Review
- Distinct neural responses of morningness and eveningness chronotype to homeostatic sleep pressure revealed by resting-state functional magnetic resonance imaging.CNS neuroscience & therapeutics · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionFunctional connectivity (FC) of the human brain's intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC. STUDY
objectivesThe aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.
methodsThirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.
resultsFundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.
conclusionDifferences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.