Evidence map›Paper›PMID 30763948›Full record

ArticleCerebrovascular diseases (Basel, Switzerland)2019

Impact of Baseline Features and Risk Factor Control on Cognitive Function in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial.

Tanya N Turan, Sami Al Kasab, Alison Smock, George Cotsonis, David Bachman, Michael J Lynn, Azhar Nizam, Colin P Derdeyn, David Fiorella, Scott Janis and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebrovascular diseases (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tanya N TuranMedical University of South Carolina, Charleston, South Carolina, USA.
Sami Al KasabDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA, sami-alkasab@uiowa.edu.
Alison SmockMedical University of South Carolina, Charleston, South Carolina, USA.
George CotsonisDepartment of Public Health, Emory University, Atlanta, Georgia, USA.
David BachmanMedical University of South Carolina, Charleston, South Carolina, USA.
Michael J LynnWashington University, St. Louis, Michigan, USA.
Azhar NizamDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Colin P DerdeynDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
David FiorellaDepartment of Neurosurgery, State University of New York at Stony Brook, Stony Brook, New York, USA.
Scott JanisNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Bethany LaneDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Jean MontgomeryDepartment of Public Health, Emory University, Atlanta, Georgia, USA.
Marc I ChimowitzMedical University of South Carolina, Charleston, South Carolina, USA.
MBChB for the SAMMPRIS Investigators

Funding

SAMMPRIS (Stenting vs. Aggressive Medical Management for Preventing . . .U01NS058728 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHIMOWITZ, MARC IVOR · 2008 to 2011
$20.0M
Characterization of Intracranial Atherosclerotic Stenosis Using HR MRIK23NS069668 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TURAN, TANYA N · 2011 to 2015
$903k
NINDS NIH HHS K23 NS069668NINDS NIH HHS U01 NS058728
6 · The paper itself

Abstract

backgroundCerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial.

methodsSubjects in the SAMMPRIS trial were included in this study. In order to have an assessment of cognitive function independent of stroke, patients with a stroke as a qualifying event whose deficits included aphasia or neglect were excluded from these analyses as were those with a cerebrovascular event during follow-up. The Montreal Cognitive Assessment (MoCA) score was used to assess cognitive impairment at baseline, 4 months, 12 months and closeout. Cognitive impairment was defined as MoCA < 26. A multivariate analysis was performed to determine what risk factors were independent predictors of cognitive function at baseline, 12 months and closeout. Among patients randomized to aggressive medical management only, the percentage of patients with cognitive impairment was compared between patients in versus out of target for each risk factor at 12 months and closeout.

resultsOf the 451 patients in SAMMPRIS, 371 patients met the inclusion criteria. MoCA < 26 was present in 55% at baseline. Older age and physical inactivity were associated with cognitive impairment at baseline. Older age, non-white race, lower baseline body mass index, and baseline cognitive impairment were associated with cognitive impairment at 12 months. In the aggressive medical management group, at 12 months, physical inactivity during follow-up was the strongest risk factor associated with cognitive impairment.

conclusionCognitive impairment is common in patients with severe symptomatic intracranial atherosclerosis. Physical inactivity at baseline and during follow-up is a strong predictor of cognitive impairment.

Indexed as

CognitionExerciseSedentary BehaviorStentsAge FactorsAngioplastyCognitive DysfunctionConstriction, PathologicHumansIntracranial ArteriosclerosisPrevalenceRecurrenceRisk AssessmentRisk FactorsStrokeTime FactorsCognitive impairmentIntracranial atherosclerosisIschemic stroke

Identifiers

PMID30763948
PMCPMC9936320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.