Evidence map›Paper›PMID 30763806›Full record

ArticleJournal of proteomics2019

Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey.

Daniel Petras, Benjamin-Florian Hempel, Bayram Göçmen, Mert Karis, Gareth Whiteley, Simon C Wagstaff, Paul Heiss, Nicholas R Casewell, Ayse Nalbantsoy, Roderich D Süssmuth

Open access · greenAbstract read
In one paragraph

Article in Journal of proteomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. The Venom ofVeterinary sciences · 2024
    Article
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  10. Review
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  12. Article
  13. Causes and Consequences of Snake Venom Variation.Trends in pharmacological sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Daniel PetrasTechnische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany; University of California San Diego, Collaborative Mass Spectrometry Innovation Center, 9500 Gilman Drive, La Jolla, CA 92093, United States. Electronic address: dpetras@ucsd.edu.
Benjamin-Florian HempelTechnische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.
Bayram GöçmenZoology Section, Department of Biology, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey.
Mert KarisZoology Section, Department of Biology, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey.
Gareth WhiteleyCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
Simon C WagstaffResearch Computing Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
Paul HeissTechnische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.
Nicholas R CasewellCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
Ayse NalbantsoyDepartment of Bioengineering, Faculty of Engineering, Ege University, Bornova 35100, Izmir, Turkey. Electronic address: analbantsoy@gmail.com.
Roderich D SüssmuthTechnische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany. Electronic address: roderich.suessmuth@tu-berlin.de.
Ege University · TRLiverpool School of Tropical Medicine · GBTechnische Universität Berlin · DEUniversity of California San Diego · US

Funding

Wellcome Trust 200517Wellcome Trust 200517/Z/16/Z
6 · The paper itself

Abstract

We report on the variable venom composition of a population of the Caucasus viper (Vipera kaznakovi) in Northeastern Turkey. We applied a combination of venom gland transcriptomics, de-complexing bottom-up and top-down venomics. In contrast to sole bottom-up venomics approaches and gel or chromatography based venom comparison, our combined approach enables a faster and more detailed comparison of venom proteomes from multiple individuals. In total, we identified peptides and proteins from 15 toxin families, including snake venom metalloproteinases (svMP; 37.8%), phospholipases A

Indexed as

Age FactorsAnimalsAntiveninsBiodiversityMass SpectrometryMetalloproteasesPhospholipases A2ProteomicsSpecies SpecificityTranscriptomeTurkeyViperidaeViper VenomsAntiveninsMetalloproteasesPhospholipases A2Viper VenomsCaucasus viperMiddle EastPopulation VenomicsSnakeSnake VenomicsTop-down VenomicsToxinTranscriptomicsVenomVipera kaznakoviViperidae

Identifiers

PMID30763806
PMCPMC7613002
OpenAlexW2912382675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.