Evidence map›Paper›PMID 30763691›Full record

ArticleMolecular and cellular neurosciences2019

Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P/Q- and N-type Ca

Anna Zaia Carolina Rodrigues, Zhong-Min Wang, María Laura Messi, Osvaldo Delbono

Abstract read
In one paragraph

Article in Molecular and cellular neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anna Zaia Carolina RodriguesDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America; Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Zhong-Min WangDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
María Laura MessiDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America.
Osvaldo DelbonoDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America; Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC, United States of America. Electronic address: odelbono@wakehealth.edu.
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Tropin T and Excitation-Contraction Coupling in Aging Skeletal MuscleR01AG013934 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 2001 to 2017
$4.7M
The Role of the Sympathetic Nervous System in the Onset and Development of SarcopeniaR01AG057013 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 2017 to 2021
$2.0M
NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG013934NIA NIH HHS R01 AG057013
6 · The paper itself

Abstract

Increasing evidence indicates that, first, the sympathetic nervous system interacts extensively with both vasculature and skeletal muscle fibers near neuromuscular junctions (NMJs) and, second, its neurotransmitter, noradrenaline, influences myofiber molecular composition and function and motor innervation. Since sympathomimetic agents have been reported to improve NMJ transmission, we examined whether two in clinical use, salbutamol and clenbuterol, affect the motor axon terminal via extracellular Ca

Indexed as

Synaptic PotentialsAlbuterolAnimalsCalcium ChannelsClenbuterolFemaleMaleMiceMice, Inbred C57BLNeuromuscular JunctionSympathomimeticsSynaptic VesiclesTRPV Cation ChannelsAlbuterolCalcium ChannelsClenbuterolSympathomimeticsTrpv5 protein, mouseTRPV Cation ChannelsCalcium channelsNeuromuscular junctionNeuromuscular transmissionSkeletal muscleSympathetic nervous systemSympathomimetics

Identifiers

PMID30763691
PMCPMC6394868
OpenAlexW2911498990

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.