Evidence map›Paper›PMID 30763654›Full record

ArticleNeuropharmacology2019

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.

Kathy Sengmany, Shane D Hellyer, Sabine Albold, Taide Wang, P Jeffrey Conn, Lauren T May, Arthur Christopoulos, Katie Leach, Karen J Gregory

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Asymmetry is central to excitatory glutamate receptor activation.Nature structural & molecular biology · 2021
    Article
  4. Review
  5. Article
  6. ACS pharmacology & translational science · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kathy SengmanyDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Shane D HellyerDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Sabine AlboldDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Taide WangDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia.
P Jeffrey ConnVanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, USA.
Lauren T MayDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Arthur ChristopoulosDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Katie LeachDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia.
Karen J GregoryDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Parkville, VIC, Australia. Electronic address: karen.gregory@monash.edu.
Monash University · AUVanderbilt University Medical Center · US

Funding

REGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Functions of Metabotropic Glutamate Receptor SubtypesR37NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2014 to 2020
$3.5M
NICHD NIH HHS U54 HD083211NIMH NIH HHS R01 MH062646NINDS NIH HHS R37 NS031373
6 · The paper itself

Abstract

Allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu

Indexed as

LigandsAllosteric RegulationAnimalsCalciumCentral Nervous SystemFemaleHEK293 CellsHumansInositol PhosphatesKineticsMicePregnancyPrimary Cell CultureRatsReceptor, Metabotropic Glutamate 5CalciumInositol PhosphatesLigandsReceptor, Metabotropic Glutamate 5Biased modulationDHPGdipraglurantfenobamGlutamateKinetics(l-glutamic acid PubChem CID: 33032)M-5MPEPMetabotropic glutamate receptor 5MPEPMTEPNegative allosteric modulator(PubChem CID: 108001)(PubChem CID: 16036762)(PubChem CID: 162834)(PubChem CID: 3025961)(PubChem CID: 44557636)(PubChem CID: 57328392)(PubChem CID: 9794218)VU0366058

Identifiers

PMID30763654
PMCPMC6420870
OpenAlexW2913510060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.