Evidence map›Paper›PMID 30763638›Full record

ArticleBiochimie2019

The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone.

Sarah R C Lentz, Pratik R Chheda, Lisa M Oppegard, Tyrell R Towle, Robert J Kerns, Hiroshi Hiasa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarah R C LentzDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Pratik R ChhedaDivision of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
Lisa M OppegardDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Tyrell R TowleDivision of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
Robert J KernsDivision of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
Hiroshi HiasaDepartment of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. Electronic address: hiasa001@umn.edu.
University of Iowa · USUniversity of Minnesota Medical Center · US

Funding

PREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8M
Predoctoral Training in the Pharmacological SciencesT32GM067795 · NIGMS · UNIVERSITY OF IOWA · PI STRACK, STEFAN · 2004 to 2021
$3.4M
Antibacterial Agents that Restrict the Emergence of ResistanceR01AI087671 · NIAID · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 2010 to 2014
$1.9M
NIAID NIH HHS R01 AI087671NIGMS NIH HHS T32 GM008365NIGMS NIH HHS T32 GM067795
6 · The paper itself

Abstract

A Mg

Indexed as

Anti-Bacterial AgentsCiprofloxacinDecarboxylationDNA, BacterialDNA GyraseEscherichia coliFluoroquinolonesMicrobial Sensitivity TestsProtein SubunitsPyrrolidinesStaphylococcus aureusSulfhydryl CompoundsAnti-Bacterial AgentsCiprofloxacinDNA, BacterialDNA GyraseFluoroquinolonesProtein SubunitsPyrrolidinesSulfhydryl CompoundsDNA gyraseDrug designFluoroquinoloneQuinolone resistanceTopoisomerase

Identifiers

PMID30763638
PMCPMC6462232
OpenAlexW2911604778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.