ArticleNeuroscience research2020
Left, right, or bilateral amygdala activation? How effects of smoothing and motion correction on ultra-high field, high-resolution functional magnetic resonance imaging (fMRI) data alter inferences.
Article in Neuroscience research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Large-Vessel Venous Signal Confounds Apparent Amygdala Activation in BOLD fMRI.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Relation between resting amygdala activity and cardiovascular events in patients with cardiac sarcoidosis.European journal of nuclear medicine and molecular imaging · 2025Article
- Perturbing whole-brain models of brain hierarchy: An application for depression following pharmacological treatment.Annals of the New York Academy of Sciences · 2025Article
- Article
- The Dichotomy of Threat and Deprivation as Subtypes of Childhood Maltreatment: Differential Functional Connectivity Patterns of Threat and Reward Circuits in an Adult Trauma Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Thalamo-cortical circuits associated with trait- and state-repetitive negative thinking in major depressive disorder.Journal of psychiatric research · 2023Article
- Spatial Smoothing Effect on Group-Level Functional Connectivity during Resting and Task-Based fMRI.Sensors (Basel, Switzerland) · 2023Article
- Effects of Parent Emotion Socialization on the Neurobiology Underlying Adolescent Emotion Processing: A Multimethod fMRI Study.Research on child and adolescent psychopathology · 2022Article
- Pre-processing of Sub-millimeter GE-BOLD fMRI Data for Laminar Applications.Frontiers in neuroimaging · 2022Article
- Imaging human engrams using 7 Tesla magnetic resonance imaging.Hippocampus · 2021Review
- From scanners to cell phones: neural and real-world responses to social evaluation in adolescent girls.Social cognitive and affective neuroscience · 2021Article
- Linking Amygdala Persistence to Real-World Emotional Experience and Psychological Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Topography of hippocampal connectivity with sensorimotor cortex revealed by optimizing smoothing kernel and voxel size.PloS one · 2021Article
- Emotional Interference in Early Adolescence: Positive Reinforcement Modulates the Behavioral and Neural Effects of Negative Emotional Distracters.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Maternal prenatal lead levels and neonatal brain volumes: Testing moderations by maternal depressive symptoms and family income.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Given the amygdala's role in survival mechanisms, and its pivotal contributions to psychological processes, it is no surprise that it is one of the most well-studied brain regions. One of the common methods for understanding the functional role of the amygdala is the use of functional magnetic resonance imaging (fMRI). However, fMRI tends to be acquired using resolutions that are not optimal for smaller brain structures. Furthermore, standard processing includes spatial smoothing and motion correction which further degrade the resolution of the data. Inferentially, this may be detrimental when determining if the amygdalae are active during a task. Indeed, studies using the same task may show differential amygdala(e) activation. Here, we examine the effects of well-accepted preprocessing steps on whole-brain submillimeter fMRI data to determine the impact on activation patterns associated with a robust task known to activate the amygdala(e). We analyzed 7T fMRI data from 30 healthy individuals collected at sub-millimeter in-plane resolution and used a field standard preprocessing pipeline with different combinations of smoothing kernels and motion correction options. Resultant amygdalae activation patterns were altered depending on which combination of smoothing and motion correction were performed, indicating that whole-brain preprocessing steps have a significant impact on the inferences that can be drawn about smaller, subcortical structures like the amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.