ArticleJAMA ophthalmology2019
Comparison of Biphasic vs Static Oxygen Saturation Targets Among Infants With Retinopathy of Prematurity.
Article in JAMA ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Retinopathy of Prematurity (ROP): Are We There Yet?Medicina (Kaunas, Lithuania) · 2026Review
- Β3-Adrenergic Receptors and Prematurity-Related Diseases: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Retinopathy of prematurity in the era of precision neonatology: from risk stratification to targeted therapies.World journal of pediatrics : WJP · 2025Article
- Development and validation of a multivariate nomogram for predicting retinopathy of prematurity in infants with gestational age ≤34 weeks.Frontiers in pediatrics · 2025Article
- Efficacy of supplemental oxygen in reducing the need for laser or intravitreal bevacizumab in preterm infants with stage 2 retinopathy of prematurity.BMC ophthalmology · 2024Article
- Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity.Italian journal of pediatrics · 2024Article
- Impact of postnatal steroids on peripheral avascular retina and severity of retinopathy of prematurity.Pediatric research · 2023Article
- Association between fetal growth-restriction and retinopathy of prematurity using a unique identical twin model.Pediatric research · 2023Article
- Article
- Hematologic Risk Factors for the Development of Retinopathy of Prematurity-A Retrospective Study.Children (Basel, Switzerland) · 2023Article
- Identifying novel candidate compounds for therapeutic strategies in retinopathy of prematurity via computational drug-gene association analysis.Frontiers in pediatrics · 2023Article
- Article
- Decoupling Oxygen Tension From Retinal Vascularization as a New Perspective for Management of Retinopathy of Prematurity. New Opportunities From β-adrenoceptors.Frontiers in pharmacology · 2022Review
- Quantification of Early Neonatal Oxygen Exposure as a Risk Factor for Retinopathy of Prematurity Requiring Treatment.Ophthalmology science · 2021Article
- Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends.Antioxidants (Basel, Switzerland) · 2021Review
- 80 Years of vision: preventing blindness from retinopathy of prematurity.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Oxygen Saturation in Infants With Retinopathy of Prematurity-Reply.JAMA ophthalmology · 2019Article
- Tailored vs Static Oxygen Saturation Targets to Prevent Retinopathy of Prematurity.JAMA ophthalmology · 2019Article
- Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors.BioMed research international · 2019Article
- Oxygenation Fluctuations Associated with Severe Retinopathy of Prematurity: Insights from a Multimodal Deep Learning Approach.Ophthalmology scienceArticle
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Importance: The Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) demonstrated that static low oxygen saturation decreased retinopathy of prematurity (ROP) but increased mortality compared with static high oxygen saturation cohorts. Objective: To compare outcomes of a biphasic oxygen protocol with static targets recommended by SUPPORT. Design, Setting, and Participants: Retrospective cohort study comparing biphasic vs static standards 41 months prior to and 42 months after a change from biphasic to static SUPPORT standards at a level III neonatal intensive care unit (Fairview Hospital, Cleveland, Ohio). The study included infants born at a corrected gestational age (CGA) of 31 weeks or younger or birth weight 1500 g or less. Data were analyzed between August 2010 and July 2017. Interventions: The pre-SUPPORT group underwent biphasic protocol target saturations of 85% to 92% at younger than 34 weeks' CGA and greater than 95% at 34 weeks' CGA or older. The post-SUPPORT group underwent a constant 91% to 95% target. Main Outcomes and Measures: Primary outcome was incidence of type 1 ROP. Secondary outcomes were incidence of any ROP, time to full vascularization, and mortality. Results: Of 596 eligible infants, 562 were included in ophthalmic analysis. Three hundred three patients were boys (54%); 399 were white (71%), 87 were black (15%), and 76 were of other or unknown race/ethnicity (14%). Mean (SD) CGA and birth weight were 29 (2) weeks and 1151 (346) g, respectively. Any ROP overall increased (53 [20%] pre-SUPPORT vs n = 86 [28%] post-SUPPORT; absolute difference, 8%; 95% CI, 1%-15%; odds ratio, 1.6; 95% CI, 1.05-2.3; P = .03). Type 1 ROP increased in the post-SUPPORT era (n = 6 [2%] pre-SUPPORT vs n = 18 [6%] post-SUPPORT; absolute difference, 4%; 95% CI, 0.4%-7%; odds ratio, 2.7; 95% CI, 1.05-6.9; P = .03). There was a delay in vascularization in the post-SUPPORT group (n = 6 [2%] pre-SUPPORT vs n = 18 [6%] post-SUPPORT; absolute difference, 4%; 95% CI, 0.4%-7%; P = .03). Conclusions and Relevance: Compared with static oxygen standards, biphasic oxygen targets are associated with decreased incidence and severity of ROP without increasing mortality.
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