Evidence map›Paper›PMID 30763397›Full record

SynthesisPloS one2019

Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis.

Judit Bajor, Zsolt Szakács, Nelli Farkas, Péter Hegyi, Anita Illés, Margit Solymár, Erika Pétervári, Márta Balaskó, Gabriella Pár, Patrícia Sarlós and 6 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Review
  3. Celiac Disease in Children: A 2023 Update.Indian journal of pediatrics · 2024
    Review
  4. Celiac Disease: A Review from Genetic to Treatment.Iranian biomedical journal · 2024
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Judit BajorDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
Zsolt SzakácsClinical Medicine Doctoral School, University of Szeged, Szeged, Hungary.ORCID 0000-0002-7035-941X
Nelli FarkasInstitute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
Péter HegyiDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
Anita IllésDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
Margit SolymárInstitute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
Erika PéterváriInstitute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
Márta BalaskóInstitute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.
Gabriella PárDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
Patrícia SarlósDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
Ákos SzűcsFirst Department of Surgery, Semmelweis University, Budapest, Hungary.
József CzimmerDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
Kata SzemesDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
Orsolya HuszárHungarian Academy of Sciences-University of Szeged, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary.
Péter VarjúInstitute for Translational Medicine, University of Pécs, Medical School, Pécs, Hungary.ORCID 0000-0002-7653-9112
Áron VinczeDivision of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.
University of Pecs · HUUniversity of Szeged · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsExperimental data suggest that the HLA-DQ2 gene dose has a strong quantitative effect on clinical outcomes and severity of celiac disease (CD). We aimed to conduct a meta-analysis with systematic review to investigate the association between HLA-DQB1*02 gene doses and the characteristics of CD.

methodsWe searched seven medical databases for studies discussing HLA-DQB1 gene dose in CD and various disease characteristics, such as clinical presentation, histology, age at diagnosis, and comorbidities. Odds ratios (OR, for categorical variables) and weighted mean differences (for age) were calculated to compare patients with a double dose of HLA-DQB1*02 versus those with single and zero doses. Heterogeneity was tested with I2-statistics and explored by study subgroups (children and adults).

resultsTwenty-four publications were eligible for meta-analysis. Classical CD was more frequent with a double versus single dose of the HLA-DQB1*02 allele (OR = 1.758, 95%CI: 1.148-2.692, I2 = 0.0%). In pediatric studies, gene dose effect was more prominent (OR = 2.082, 95%CI: 1.189-3.646, I2 = 0.0% and OR = 3.139, 95%CI: 1.142-8.630, I2 = 0.0% for the comparisons of double versus single and double versus zero dose, respectively). Atrophic histology was more prevalent with a double versus zero dose (OR = 2.626, CI: 1.060-6.505, I2 = 21.3%). We observed no gene dose effect regarding diarrhea, age at diagnosis, the severity of villous atrophy, and the association with type 1 diabetes mellitus.

conclusionA double dose of HLA-DQB1*02 gene seems to predispose patients to developing classical CD and villous atrophy. Risk stratification by HLA-DQB1*02 gene dose requires further clarification due to the limited available evidence.

Indexed as

AllelesCeliac DiseaseDatabases, FactualGene DosageHLA-DQ beta-ChainsHumansOdds RatioSeverity of Illness IndexHLA-DQB1 antigenHLA-DQ beta-Chains

Identifiers

PMID30763397
PMCPMC6375622
OpenAlexW2914232292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.