ArticlePloS one2019
The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The impact of frailty scores on latent tuberculosis infection and all-cause mortality in this population.Medicine · 2026Article
- Prevalence and risk factors of cognitive frailty in people with HIV.AIDS (London, England) · 2026Observational
- Potential Noninvasive Biomarkers to Assess the Aging Process.Expert reviews in molecular medicine · 2025Review
- Predictors of frailty trajectories among people with HIV.AIDS (London, England) · 2025Observational
- Predicting neurocognitive decline in older persons living with VIH: a spotlight on the T-CD4 + /CD8 + ratio.European geriatric medicine · 2025Article
- Bone Mineral Density and Trabecular Bone Score Changes throughout Menopause in Women with HIV.Viruses · 2023Observational
- Review
- Decrypting biological hallmarks of aging in people with HIV.Current opinion in HIV and AIDS · 2023Review
- Systemic immune response in young and elderly patients after traumatic brain injury.Immunity & ageing : I & A · 2023Article
- Reduced probability of improving viro-immunological state in subjects with vertical transmission of HIV reaching adult age: A multicenter retrospective cohort study.Immunity, inflammation and disease · 2023Article
- Determining reference ranges for immunological cells of healthy indigenous individuals from a region in Brazil.Einstein (Sao Paulo, Brazil) · 2023Article
- Frailty in older people living with HIV: current status and clinical management.BMC geriatrics · 2022Review
- Switching to a Bictegravir Single Tablet Regimen in Elderly People Living with HIV-1: Data Analysis from the BICTEL Cohort.Diagnostics (Basel, Switzerland) · 2021Article
- Aging Aggravates Cachexia in Tumor-Bearing Mice.Cancers · 2021Article
- Review
- Effect of Traditional Chinese Medicine Therapy on the Trend in CD4Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Characteristics of Motor Dysfunction in Longstanding Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- COVID-19 and the elderly: insights into pathogenesis and clinical decision-making.Aging clinical and experimental research · 2020Review
- Clinical management of ageing people living with HIV in Europe: the view of the care providers.Infection · 2020Article
- Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults.BMC research notes · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between current CD4+ T-cell count and CD4/CD8+ ratio with severity of frailty among people aging with HIV.
methodsCross-sectional observational study analysing data from all study visits in the ongoing prospective Modena HIV Metabolic Clinic Cohort between 2006 and 2015. Frailty severity was assessed using a frailty index (FI). We visualized the relationships between frailty index score and current CD4 cell count and CD4/CD8 ratio on two different curves adjusted for age, sex, and duration of HIV infection.
resultsFrailty index scores exhibited an inverse relationship with current CD4 count, up to 900 cells/μL. The CD4/CD8 ratio was inversely correlated with frailty index both below and above the cut-off of 900 CD4 cells/μL.
conclusionsFrailty in PLWH is inversely associated with both immune-activation, depicted by CD4/CD8 ratio and immune-deficit depicted by CD4 count. The first association shows a linear shape while the second shows a hook-shape with a turning point at 900 cells. Above this cut off level CD4 do not represent a significant risk factor for frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.