Observational studyEuropean journal of endocrinology2019
Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study.
Observational study in European journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Polycystic ovary syndrome in obstructive sleep apnea-hypopnea syndrome: an updated meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Sleep disturbances, sleep quality, and cardiovascular risk factors in women with polycystic ovary syndrome: Systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Different sleep pattern in over-weight/obese women with polycystic ovary syndrome.Frontiers in endocrinology · 2023Trial
- Polycystic Ovary Syndrome and Subjective and Objective Assessments of Sleep Quality: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Advances in the Diagnosis and Treatment of Obstructive Sleep Apnea in Women.Pulmonary therapy · 2026Review
- Obstructive Sleep Apnea and Female Reproductive Endocrine Diseases: A Mendelian Randomization and Mediation Analysis.International journal of endocrinology · 2026Article
- Clinical characteristics and pregnancy outcomes in polycystic ovary syndrome complicated by obstructive sleep apnea: a correlative study.Frontiers in medicine · 2026Article
- Causal effect of potential risk factors on obstructive sleep apnea: a Mendelian randomization study.Future science OA · 2025Article
- Osteoarthritis and the risk of sleep apnea: a general population-based cohort study.Clinical rheumatology · 2025Article
- Causal evidence of the relationship between polycystic ovary syndrome and obstructive sleep apnea in European and East Asian populations: a two-sample Mendelian randomization study.Journal of thoracic disease · 2024Article
- Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women.JAMA network open · 2024Article
- Metabolic and endocrine status associate with obstructive sleep apnea risk among patients with polycystic ovary syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Prevalence and Clinical Management of Adrenal Tumour-Related Hyperandrogenism: A Narrative Review.Life (Basel, Switzerland) · 2024Review
- Association of obstructive sleep apnea syndrome with polycystic ovary syndrome through bidirectional Mendelian randomization.Frontiers in medicine · 2024Article
- Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Longitudinal prospective cohort study evaluating prognosis in idiopathic intracranial hypertension patients with and without comorbid polycystic ovarian syndrome.Eye (London, England) · 2023Article
- The Menstrual Cycle and Sleep.Sleep medicine clinics · 2023Review
- Efficacy of serum anti-mullerian hormone (AMH) levels for prediction of polycystic ovary syndrome (PCOS) and its association with clinical, biochemical and hormonal parameters.Indian journal of clinical biochemistry : IJCB · 2023Article
- Dysregulation of immune response in PCOS organ system.Frontiers in immunology · 2023Review
- Approach to androgen excess in women: Clinical and biochemical insights.Clinical endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveObesity is very common in patients with obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS). Longitudinal studies assessing OSA risk in PCOS and examining the role of obesity are lacking. Our objective was to assess the risk of OSA in women with vs without PCOS and to examine the role of obesity in the observed findings.
designPopulation-based retrospective cohort study utilizing The Health Improvement Network (THIN), UK.
methods76 978 women with PCOS and 143 077 age-, BMI- and location-matched women without PCOS between January 2000 and May 2017 were identified. Hazard ratio (HR) for OSA among women with and without PCOS were calculated after controlling for confounding variables using multivariate Cox models.
resultsMedian patient age was 30 (IQR: 25-35) years; median follow-up was 3.5 (IQR: 1.4-7.1) years. We found 298 OSA cases in PCOS women vs 222 in controls, with incidence rates for OSA of 8.1 and 3.3 per 10 000 person years, respectively. Women with PCOS were at increased risk of developing OSA (adjusted HR = 2.26, 95% CI: 1.89-2.69, P < 0.001), with similar HRs for normal weight, overweight and obese PCOS women.
conclusionsWomen with PCOS are at increased risk of developing OSA compared to control women irrespective of obesity. Considering the significant metabolic morbidity associated with OSA, clinicians should have a low threshold to test for OSA in women with PCOS. Whether OSA treatment has an impact on PCOS symptoms and outcomes needs to be examined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.