ReviewJournal of veterinary internal medicine2019
Comparative pathophysiology and management of protein-losing enteropathy.
Review in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 109 citations in OpenAlex.
- Feline chronic diarrhea: causes and nutritional management.Veterinary and animal science · 2026Review
- Proteomics in Gastrointestinal Diseases of Companion Animals: Current State and Knowledge Gaps.Animals : an open access journal from MDPI · 2026Review
- Reply to letter regarding "ACVIM-endorsed statement: consensus statement and systematic review on guidelines for the diagnosis and treatment of chronic inflammatory enteropathy in dogs".Journal of veterinary internal medicine · 2026Article
- Association of hypoalbuminemia with disease and survival in 1664 cats presenting to a tertiary teaching hospital: a retrospective case-control study.Journal of veterinary internal medicine · 2026Article
- Retrospective Analysis of Antibiotic Use in Dogs with Chronic Inflammatory Enteropathy Prior to Referral: 144 Cases (2020-2024).Animals : an open access journal from MDPI · 2026Article
- Clinical management and outcomes for 51 Pugs reportedly diagnosed with protein-losing enteropathy using VetCompass primary care veterinary data.The Journal of small animal practice · 2026Article
- Anti-Inflammatory and Antioxidant Effects of Quercetin, Luteolin, and Proanthocyanidins in Canine PBMCs Stimulated withAnimals : an open access journal from MDPI · 2025Article
- Prognosis for surgical intestinal resection in inflammatory bowel disease refractory to medical treatment in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- A prospective single-arm study on the effects of repeated intravenous infusions of canine adipose-derived mesenchymal stromal cells in dogs with chronic inflammatory enteropathy.Stem cell research & therapy · 2025Article
- Retrospective evaluation of short- and medium-term therapeutic response to different immunosuppressive and dietary approaches in 148 dogs diagnosed with immunosuppressant-responsive enteropathy.Open veterinary journal · 2025Article
- Intestinal Vicarious Contrast Medium Excretion on Delayed Computed Tomography in Dogs with Protein-Losing Enteropathy.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2025Article
- Protein-Losing Enteropathy Demonstrated byDiagnostics (Basel, Switzerland) · 2025Article
- An extensively hydrolysed protein-based extruded diet in the treatment of dogs with chronic enteropathy and at least one previous diet-trial failure: a pilot uncontrolled open-label study.BMC veterinary research · 2025Article
- Efficacy of Anthelmintics Against Canine Hookworm Infections in the Bono East Region of Ghana.Journal of parasitology research · 2025Article
- Glucocorticoids do not cause a clinically relevant elevation in the urine protein-to-creatinine ratio in dogs with inflammatory protein-losing enteropathy.Frontiers in veterinary science · 2025Article
- Abundance of bacteria and histopathologic findings in the small intestinal mucosa of dogs with chronic inflammatory enteropathies.PloS one · 2025Article
- Case Report: Disseminated primary pulmonary carcinoma presenting as a chronic enteropathy in a dog.Frontiers in veterinary science · 2025Article
- Detection of protein-losing enteropathy (PLE) ultrasonographic imaging features in dogs using deep learning neural networks.Frontiers in artificial intelligence · 2025Article
- Protein-losing enteropathy with congenital kidney stones in a 2-month-old boy: a rare case report and literature review.BMC medical genomics · 2024Review
- A comprehensive review of paratuberculosis in animals and its implications for public health.Open veterinary journal · 2024Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-losing enteropathy, or PLE, is not a disease but a syndrome that develops in numerous disease states of differing etiologies and often involving the lymphatic system, such as lymphangiectasia and lymphangitis in dogs. The pathophysiology of lymphatic disease is incompletely understood, and the disease is challenging to manage. Understanding of PLE mechanisms requires knowledge of lymphatic system structure and function, which are reviewed here. The mechanisms of enteric protein loss in PLE are identical in dogs and people, irrespective of the underlying cause. In people, PLE is usually associated with primary intestinal lymphangiectasia, suspected to arise from genetic susceptibility, or "idiopathic" lymphatic vascular obstruction. In dogs, PLE is most often a feature of inflammatory bowel disease (IBD), and less frequently intestinal lymphangiectasia, although it is not proven which process is the true driving defect. In cats, PLE is relatively rare. Review of the veterinary literature (1977-2018) reveals that PLE was life-ending in 54.2% of dogs compared to published disease-associated deaths in IBD of <20%, implying that PLE is not merely a continuum of IBD spectrum pathophysiology. In people, diet is the cornerstone of management, whereas dogs are often treated with immunosuppression for causes of PLE including lymphangiectasia, lymphangitis, and crypt disease. Currently, however, there is no scientific, extrapolated, or evidence-based support for an autoimmune or immune-mediated mechanism. Moreover, people with PLE have disease-associated loss of immune function, including lymphopenia, severe CD4+ T-cell depletion, and negative vaccinal titers. Comparison of PLE in people and dogs is undertaken here, and theories in treatment of PLE are presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.