Evidence map›Paper›PMID 30762896›Full record

ArticleHepatology (Baltimore, Md.)2019

Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/β-Catenin Signaling.

Ludan Zhao, Yinhua Jin, Katie Donahue, Margaret Tsui, Matt Fish, Catriona Y Logan, Bruce Wang, Roel Nusse

Abstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Towards a reference cell atlas of liver diversity over the human lifespan.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Liver macrophages: development, dynamics, and functions.Cellular & molecular immunology · 2025
    Review
  14. MST1/2 DKO abates salvianolic acid B's therapeutic effect on CClNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ludan ZhaoInstitute for Stem Cell Biology and Regenerative Medicine, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, CA.
Yinhua JinInstitute for Stem Cell Biology and Regenerative Medicine, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, CA.
Katie DonahueInstitute for Stem Cell Biology and Regenerative Medicine, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, CA.
Margaret TsuiDepartment of Medicine and Liver Center, University of California San Francisco, San Francisco, CA.
Matt FishInstitute for Stem Cell Biology and Regenerative Medicine, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, CA.
Catriona Y LoganInstitute for Stem Cell Biology and Regenerative Medicine, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, CA.
Bruce WangInstitute for Stem Cell Biology and Regenerative Medicine, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, CA.
Roel NusseInstitute for Stem Cell Biology and Regenerative Medicine, Department of Developmental Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, CA.
Howard Hughes Medical Institute · USUniversity of California, San Francisco · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Wnt signaling in hepatocyte homeostasisK08DK101603 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, BRUCE MAO ZHENG · 2015 to 2019
$829k
NIDDK NIH HHS K08 DK101603NIDDK NIH HHS P30 DK026743NIGMS NIH HHS T32 GM007365
6 · The paper itself

Abstract

In the liver, Wnt/β-catenin signaling is involved in regulating zonation and hepatocyte proliferation during homeostasis. We examined Wnt gene expression and signaling after injury, and we show by in situ hybridization that Wnts are activated by acute carbon tetrachloride (CCl

Indexed as

AnimalsAxin Proteinbeta CateninBiopsy, NeedleCarbon TetrachlorideCells, CulturedDisease Models, AnimalGene ExpressionHepatocytesImmunohistochemistryLiverLiver RegenerationMaleMiceMice, Inbred C57BLPolymerase Chain ReactionAxin2 protein, mouseAxin Proteinbeta CateninCarbon TetrachlorideRNAWnt Proteins

Identifiers

PMID30762896
PMCPMC7043939
OpenAlexW2907359354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.